通过过渡金属催化的 C-H 功能化利用烯酮化学性质

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-04-01 DOI:10.1002/ajoc.202400768

Zhiming Feng , Yushan Xie , Lili Wu , Prof. Chengming Wang

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引用次数: 0

摘要

过渡金属催化的C- H功能化已经成为现代有机合成的基石，它能够有效地形成各种C- C和C-杂原子键。烯酮是一类高活性和多功能分子，最近被用作C−H功能化反应的强大底物，为构建复杂分子框架提供了新的可能性。本文综述了过渡金属催化的烯酮催化C - H功能化的最新进展，包括新型催化体系的设计、反应机理的阐明和合成应用的探索。通过强调当前的艺术状态，挑战和未来的前景，这一概念旨在激发这一快速发展领域的进一步研究和创新，最终扩大过渡金属催化的碳-氢功能化与烯酮的前沿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Harnessing the Ketene Chemistry by Transition‐Metal‐Catalyzed C−H Functionalization

Transition‐metal‐catalyzed C−H functionalization has become a cornerstone of modern organic synthesis, enabling the efficient formation of various C−C and C‐heteroatom bonds. Ketenes, a class of highly reactive and versatile molecules, have recently been harnessed as powerful substrates for C−H functionalization reactions, unlocking new possibilities for the construction of complex molecular frameworks. This review provides a comprehensive overview of the latest advances in transition‐metal‐catalyzed C−H functionalization with ketenes, encompassing the design of novel catalytic systems, elucidation of reaction mechanisms, and exploration of synthetic applications. By highlighting the current state of the art, challenges, and future prospects, this concept aims to inspire further research and innovation in this rapidly evolving field, ultimately expanding the frontiers of transition‐metal‐catalyzed C−H functionalization with ketenes.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.