氟虫脲对春尾虫生活史性状的影响从其脂质代谢障碍解释

IF 8.2 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Science of the Total Environment Pub Date : 2025-04-18 DOI:10.1016/j.scitotenv.2025.179394

Diana Ilyaskina , Saúl Fernandes , Matty P. Berg , Marja H. Lamoree , Cornelis A.M. van Gestel , Pim E.G. Leonards

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引用次数: 0

摘要

本研究调查了杀虫剂四氟苯脲如何扰乱念珠绣春蝽的脂质代谢，发现其脂质谱发生了显著变化。将 F. candida 暴露于亚致死浓度的特氟隆（0, 0.006, 0.014, 0.035 mg a.s. kg-1 土壤干重）。非靶向脂质组学用于研究春尾鱼在 2 天、7 天和 14 天的暴露间隔内脂质特征的动态变化。特氟苯脲诱导了脂质图谱的变化，影响了对能量储存、膜完整性和信号传递至关重要的脂质通路，而这些通路对这种春尾鱼的生存、繁殖和应激反应至关重要。二酰甘油（DG）和三酰甘油（TG）在能量储存和脂质介导的信号传导中发挥着关键作用，它们受到特氟苯磺隆的严重影响。DG 和 TG 含量的降低表明，四氟苯脲的作用重点已从繁殖功能转向维持功能，这意味着胆固醇稳态和卵黄发生受到了破坏。此外，暴露于四氟苯脲后脂肪酸和 N-乙酰乙醇胺水平升高，表明能量生成增加和潜在的氧化应激，突显了春蜱对农药暴露的反应。某些脂质变化（N-棕榈酰乙醇胺（NAE 16:0）和 N-硬脂酰乙醇胺（NAE 18:0））以其抗炎特性而闻名，这些变化指向炎症和线粒体膜重塑（心磷脂脂质的变化），表明对生理功能产生了更广泛的影响。醚甘油磷脂（如溶血磷脂酰乙醇胺和磷脂酰乙醇胺）与过氧化物酶体和内质网有关，强调了它们在应对氧化应激时的潜在抗氧化作用。这项研究表明，将生命周期事件纳入生态毒理学评估，对于全面了解农药对生物的影响具有重要意义。将脂质组学纳入环境风险评估为农药监管和环境管理提供了一种更明智的方法。

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Teflubenzuron effects on springtail life history traits explained from impairment of its lipid metabolism

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Teflubenzuron effects on springtail life history traits explained from impairment of its lipid metabolism

This study investigated how the insecticide teflubenzuron disrupts lipid metabolism in the springtail Folsomia candida, revealing significant alterations in lipid profiles. F. candida was exposed to sub-lethal concentrations of teflubenzuron (0, 0.006, 0.014, 0.035 mg a.s. kg⁻¹ soil dry weight). Untargeted lipidomics was used to study the dynamic changes in lipid profiles in the springtail over exposure intervals of 2, 7, and 14 days exposure intervals. Teflubenzuron induced shifts in lipid profiles, affecting lipid pathways crucial for energy storage, membrane integrity, and signaling, which are essential for survival, reproduction, and stress responses in this springtail. Diacylglycerols (DG) and Triacylglycerols (TG), which play crucial roles in energy storage and lipid-mediated signaling, were substantially affected by teflubenzuron. Decreased levels of DG and TG suggest a shift in priorities from reproduction to maintenance functions, implying disruptions in cholesterol homeostasis and vitellogenesis in response to teflubenzuron exposure. Furthermore, increased levels of fatty acids and N-acylethanolamines in response to teflubenzuron exposure indicated increased energy production and potential oxidative stress, highlighting the springtails' response to pesticide exposure. Certain lipid alterations (N-palmitoylethanolamine (NAE 16:0) and N-stearoylethanolamine (NAE 18:0)), known for their anti-inflammatory properties, point towards inflammation and mitochondrial membrane remodeling (alternations in cardiolipin lipids), indicating broader impacts on physiological functions. Ether glycerophospholipids, such as lysophosphatidylethanolamine and phosphatidylethanolamine, linked to peroxisomes and the endoplasmic reticulum, underscore their potential antioxidative role in response to oxidative stress. The study shows the significance of incorporating life cycle events into ecotoxicological assessments to comprehensively understand pesticide impacts on organisms. The integration of lipidomics into environmental risk assessments offers a more informed approach to pesticide regulation and environmental stewardship.

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来源期刊

Science of the Total Environment 环境科学-环境科学

CiteScore

17.60

自引率

10.20%

发文量

8726

审稿时长

2.4 months

期刊介绍： The Science of the Total Environment is an international journal dedicated to scientific research on the environment and its interaction with humanity. It covers a wide range of disciplines and seeks to publish innovative, hypothesis-driven, and impactful research that explores the entire environment, including the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. The journal's updated Aims & Scope emphasizes the importance of interdisciplinary environmental research with broad impact. Priority is given to studies that advance fundamental understanding and explore the interconnectedness of multiple environmental spheres. Field studies are preferred, while laboratory experiments must demonstrate significant methodological advancements or mechanistic insights with direct relevance to the environment.