多价蛇类抗蛇毒血清对三种蝰蛇（Vipera berus berus；Linnaeus，1758；Vipera ammodytes ammodytes；Linnaeus，1758 和 Montivipera raddei；Boettger，1890）毒液副特异性影响的研究

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2025-04-12 DOI:10.1016/j.toxicon.2025.108349

Yasemin Numanoglu Cevik , Derya Altun , Metin Serin , Edibe Nurzen Namli Bozkurt , Ilhan Bozyigit , Halit Ozkan Icigen , Mehmet Ali Kanat

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引用次数: 0

摘要

目的观察土耳其用于治疗蛇咬伤中毒的国家hsgm多价蛇毒血清对广泛分布于欧洲的蝰蛇（Vipera ammodytes ammodytes）和蝰蛇（Vipera berus berus）以及土耳其和亚美尼亚的raddei Montivipera毒液的副效。方法采用欧洲药典规定的抗蛇毒血清小鼠毒效中和试验方法，测定抗蛇毒血清对三种毒的效价。结论HSGM-PVSAV对三种蛇毒的抑毒作用均超过欧洲药典限量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Investigation of paraspecific effects of polyvalent snake antivenom on the venom of three vipers (Vipera berus berus; Linnaeus 1758, Vipera ammodytes ammodytes; Linnaeus, 1758 and Montivipera raddei; Boettger, 1890)

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Objective

The aim was to investigate the paraspecific efficiacy of the National HSGM-polyvalent snake antivenom, which is used in the treatment of snakebite poisoning cases in Turkey, on Vipera ammodytes ammodytes and Vipera berus berus snakes that live widely in Europe and Montivipera raddei venoms that live in Turkey and Armenia.

Method

The paraspecific efficiacy of the antivenom on these three venoms were determined using the test method for neutralization of the lethal effect of the venom in mice specified in the European pharmacopoeia.

Conclusion

It was observed that HSGM-PVSAV produced using Vipera ammodytes montandoni, Macrovipera lebetina obtusa and Montivipera xanthina venoms showed an effect above the European pharmacopoeia limits against all three snake venoms.

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

期刊介绍： Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee. Toxicon''s "aims and scope" are to publish: -articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms -papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins -molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins -clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained. -material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems. -articles on the translational application of toxins, for example as drugs and insecticides -epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged. -articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon. -review articles on problems related to toxinology. To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.