基于Tamaru反应的可再生资源合成麝香酮及其类似物的方法

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-04-18 DOI:10.1016/j.tetlet.2025.155593

Santosh J. Gharpure, Saidurga Prasad Kommyreddy

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引用次数: 0

摘要

麝香被认为是香水之王，由于其罕见的出现和异国情调的性质，许多人尝试合成麝香类似物。酮的C-3位甲基的存在使分子具有麝香的性质。Tamaru反应（ni催化的醛与1,3-二烯的还原偶联反应）是有效安装甲基以提供RCM前体二烯的关键步骤。一个包含氧化、RCM和还原的短三步序列提供了对muscone和类似物的高效访问。前体醛和异戊二烯均来源于可再生资源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Tamaru reaction-based approach towards the synthesis of muscone and analogues using renewable sources

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Tamaru reaction-based approach towards the synthesis of muscone and analogues using renewable sources

Muscone is considered as the king of fragrances, due to its rare occurrence and exotic nature, many attempts have been made to synthesise musk analogues. The presence of methyl group at the C-3 position from ketone imparts the musk character to the molecule. The Tamaru reaction (Ni-catalysed reductive coupling of aldehyde and 1,3-dienes) is used as the key step for the installation of the methyl group in an efficient manner to afford the RCM precursor diene. A short three step sequence involving oxidation, RCM and reduction gave a highly efficient access to muscone and analogues. Both the precursors, namely, the aldehyde and isoprene are derived from renewable resource.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.