1990 - 2019年全球异位妊娠负担：基于2019年全球疾病负担研究的趋势、预测趋势和不平等分析

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-04-09 DOI:10.1016/j.ejogrb.2025.113957

Wenwen Chen , Yuanzhi Zhou , Xu Zhang , Xinyu Xu , Yan Yin , Shuixiang He

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引用次数: 0

摘要

异位妊娠（EP）是一种危险的产科疾病，在世界任何地方都可能发生。本研究旨在探讨与急性脑卒中相关的负担、健康不平等分析和未来趋势，以协助制定公共卫生政策的下一步措施。方法根据《2019年全球疾病负担》（global Burden of Disease 2019）对全球、地区和国家人群按年龄、年龄和社会经济水平分类的EP流行病学特征进行评估。本研究分析了发病率、死亡率、残疾调整生命年（DALYs）、年龄标准化率（ASR）；平均年变化百分比（AAPC）和估计年变化百分比（EAPC）。这篇文章进一步预测了未来30年的变化，并量化了跨国卫生不平等。结果2019年全球新发病例数为6,692,404.75例（95% UI = 5,225,400.95-8,598,569.75），与1990年的7,453,267.43例（95% UI = 5,738,984.72-9,557,077.85）相比有所下降；年龄标准化死亡率（ASDR）为0.16 (95% UI = 0.14 ~ 0.19)，较1990年的0.22 （95% UI = 0.19 ~ 0.24）略有下降。ASDR的EAPC平均每年下降- 0.91 （95% CI = -1.04 - -0.78）。此外，EP的ASR DALYs从1990年的12.46 （95% UI = 11.09-13.91）下降到2019年的9.69 （95% UI = 8.27-11.31）。预测表明，到2049年，ASIR将上升到149.91 (95% UI = 11.77-288.05)， ASDR将上升到0.18 （95% UI = 0.05-0.31）。EP死亡和DALYs浓度指数在1990 - 2019年间呈上升趋势。健康不平等表明，EP DALY比率的浓度指数从1990年的-0.46 （95% CI = -0.55至-0.38）下降到2019年的-0.61 (95% CI = -0.70至-0.52)，EP死亡浓度指数从1990年的-0.47 （95% CI = -0.56至-0.39）下降到2019年的-0.62 （95% CI = -0.71至-0.53）。结论本研究强调了EP的严重负担，特别是在社会人口指数较低的国家。解决保健不平等问题对于制定有效的干预政策以改善全球孕产妇保健成果至关重要。

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Global burden of ectopic pregnancy from 1990 to 2019: A tendency, forecasted trend and inequality analyses based on the Global Burden of Disease Study 2019

Background

Ectopic pregnancy (EP) is a dangerous obstetric condition that can occur anywhere throughout the world. This study explored the burden, health inequality analysis, and future trends related to EP to assist in formulating the next steps of public health policies.

Methods

The epidemiological characteristics of EP classified by age, year, and socioeconomic level were assessed in global, regional, and national groups based on Global Burden of Disease 2019. This study analyzed incidence, mortality, disability-adjusted life years (DALYs), age-standardized rate (ASR); average annual percentage change (AAPC), and estimated annual percentage change (EAPC). The article further predicts its change over the next 30 years and quantifies cross-national health inequalities.

Results

In 2019, the global number of new cases was 6,692,404.75 (95 % UI = 5,225,400.95–8,598,569.75), a decrease from 7,453,267.43 (95 % UI = 5,738,984.72–9,557,077.85) in 1990; and the age-standardized deaths rate (ASDR) was 0.16 (95 % UI = 0.14–0.19), a slight decrease from 0.22 (95 % UI = 0.19–0.24) in 1990. The EAPC for ASDR showed an average annual decrease of −0.91 (95 % CI = -1.04 − -0.78). In addition, ASR DALYs of EP decreased from 12.46 (95 % UI = 11.09–13.91) in 1990 to 9.69 (95 % UI = 8.27–11.31) in 2019. Projections indicate that by 2049, the ASIR will rise to 149.91 (95 % UI = 11.77–288.05) and the ASDR will rise to 0.18 (95 % UI = 0.05–0.31). Concentration indices of EP death and DALYs increased between 1990 and 2019. Health inequalities show that the concentration index for the EP DALY ratio decreased from -0.46 (95 % CI = -0.55 to -0.38) in 1990 to -0.61 (95 % CI = -0.70 to -0.52) in 2019 and the concentration index for EP death decreased from -0.47 (95 %CI = -0.56 to -0.39) in 1990 to -0.62 (95 %CI = -0.71- -0.53) in 2019.

Conclusions

This study emphasizes the significant burden of EP, especially for low socio-demographic index countries. Addressing health inequality is crucial for developing effective intervention policies to improve global maternal health outcomes.

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.