靶诱导光敏氧化法快速超灵敏检测四环素类抗生素

IF 3.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL
Yao Lin , Yi Ye , Zhankuo Zhang , Xiaoyu Zi , Jinyi Zhang , Chengbin Zheng
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引用次数: 0

摘要

四环素类药物的过度使用已导致其对公众健康和环境的潜在风险。因此,快速、准确、灵敏地检测环境样品中的tc对于生态监测和保障公众健康至关重要。然而,现有的基于过氧化物酶样活性的比色分析策略通常涉及纳米材料合成,并且受选择性和灵敏度差的限制。在这项研究中,我们发现了TCs在紫外光诱导下光催化氧化显色底物的特性。为了进一步提高TCs响应比色法的选择性,引入Gd3+使TCs的吸收红移,避免易吸收紫外光的物质的干扰。此外,开发了核苷酸- gd3 +纳米材料(GMP-Gd3+-NPs),通过简单的混合和离心来实现tc的浓度,实现了高灵敏度的tc响应比色检测。在优化条件下,四环素、土霉素和金四素的检出限分别低至2.9 nM、2.7 nM和4.3 nM。与其他比色策略相比,该方法保留了选择性和良好的光催化活性,为环境监测中TCs的测定提供了巨大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Target-induced photosensitization oxidation for rapid and ultrasensitive colorimetric detection of tetracycline antibiotics
Excessive use of tetracyclines (TCs) has led to their potential risks to public health and the environment. Therefore, rapid, accurate, and sensitive detection of TCs in environmental samples is crucial for ecological monitoring and safeguarding public health. However, the available colorimetric strategies based on peroxidase-like activity for the analysis of TCs usually involve nanomaterial synthesis and are limited by poor selectivity and sensitivity. In this study, we found that TCs characteristics with photocatalytic oxidation of chromogenic substrates induced by ultraviolet light. To further improve the selectivity of TCs-responsive colorimetry, Gd3 + was introduced to redshift the absorption of TCs to avoid the interference of substances that easily absorb ultraviolet light. Besides, nucleotide-Gd3+ nanomaterials (GMP-Gd3+-NPs) was developed to achieve the concentration of TCs through simple mixing and centrifugation, allowing a highly sensitive TCs-responsive colorimetric detection. Under optimized conditions, the detection limits for tetracycline, oxytetracycline, and chlortetracycline were as low as 2.9 nM, 2.7 nM, and 4.3 nM, respectively. Compared to other colorimetric strategies, this developed GMP-Gd3+-TCs retains selectivity and excellent photocatalytic activity performance, providing great potential in the determination of TCs in environmental monitoring.
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来源期刊
Sensors and Actuators B: Chemical
Sensors and Actuators B: Chemical 工程技术-电化学
CiteScore
14.60
自引率
11.90%
发文量
1776
审稿时长
3.2 months
期刊介绍: Sensors & Actuators, B: Chemical is an international journal focused on the research and development of chemical transducers. It covers chemical sensors and biosensors, chemical actuators, and analytical microsystems. The journal is interdisciplinary, aiming to publish original works showcasing substantial advancements beyond the current state of the art in these fields, with practical applicability to solving meaningful analytical problems. Review articles are accepted by invitation from an Editor of the journal.
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