多模式人群研究揭示了生物钟的神经生物学基础

IF 21.4 1区 心理学 Q1 MULTIDISCIPLINARY SCIENCES
Le Zhou, Karin Saltoun, Julie Carrier, Kai-Florian Storch, Robin I. M. Dunbar, Danilo Bzdok
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引用次数: 0

摘要

社会的快速变化改变了人类的行为模式,增加了夜间活动,增加了看屏幕的时间,改变了睡眠时间表。作为昼夜节律的明确表现,时间型与身心健康密切相关。与早起的人相比,夜猫子往往表现出不健康的生活习惯,更容易受到情绪障碍的影响,身体素质也更差。尽管生物钟的个体差异会产生不同的结果,但其神经生物学基础仍然难以捉摸。在这里,我们使用三种脑成像模式(灰质体积、白质完整性和功能连接)进行了模式学习分析,并利用了27,030名英国生物银行参与者的976种表型。由此产生的多层次分析揭示了基底神经节、边缘系统、海马和小脑的收敛性。通过模拟可穿戴设备的日常运动数据得出的模式进一步突出了这些关键的大脑特征。总的来说,我们在人群水平上的研究全面地研究了时间类型,强调了它与习惯形成、奖励加工和情绪调节的密切联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Multimodal population study reveals the neurobiological underpinnings of chronotype

Multimodal population study reveals the neurobiological underpinnings of chronotype

The rapid shifts in society have altered human behavioural patterns, with increased evening activities, increased screen time and changed sleep schedules. As an explicit manifestation of circadian rhythms, chronotype is closely intertwined with physical and mental health. Night owls often exhibit unhealthier lifestyle habits, are more susceptible to mood disorders and have poorer physical fitness compared with early risers. Although individual differences in chronotype yield varying consequences, their neurobiological underpinnings remain elusive. Here we conducted a pattern-learning analysis with three brain-imaging modalities (grey matter volume, white-matter integrity and functional connectivity) and capitalized on 976 phenotypes in 27,030 UK Biobank participants. The resulting multilevel analysis reveals convergence on the basal ganglia, limbic system, hippocampus and cerebellum. The pattern derived from modelling actigraphy wearables data of daily movement further highlighted these key brain features. Overall, our population-level study comprehensively investigates chronotype, emphasizing its close connections with habit formation, reward processing and emotional regulation.

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来源期刊
Nature Human Behaviour
Nature Human Behaviour Psychology-Social Psychology
CiteScore
36.80
自引率
1.00%
发文量
227
期刊介绍: Nature Human Behaviour is a journal that focuses on publishing research of outstanding significance into any aspect of human behavior.The research can cover various areas such as psychological, biological, and social bases of human behavior.It also includes the study of origins, development, and disorders related to human behavior.The primary aim of the journal is to increase the visibility of research in the field and enhance its societal reach and impact.
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