Yandi Zhang, Wenjun Wang, Xiaoru Yang, Xuanmeng An, Xiaoyi Liu, Weiwei Zhao, Lina Zhu, Ting Wang, Ying Wang, Yi Chen, Junkun Feng, Jinlong Shao, Xuedong Zhou, Ben Zhong Tang, Shaohua Ge, Jianhua Li
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Inside Back Cover: Molecular Diagnosis and Therapy of Dental Caries by Oral Microbiome-Selective Aggregation-Induced Photosensitivity
This study introduces an aggregation-induced emission probe, MeOTpy, for instant molecular detection and photodynamic treatment of dental caries. MeOTpy exhibited bright fluorescence upon binding to cariogenic pathogens and generating reactive oxygen species under white light irradiation. This aggregation-induced photosensitivity enables rapid assessment of carious disease in human dental plaque samples and prevented dental caries on rat pups (e733).
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