封面特征：紫草素衍生物通过活性氧介导的线粒体凋亡和PI3K/AKT通路抑制结直肠癌细胞的生长。生物多样性的4/2025)

IF 2.5 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-04-17 DOI:10.1002/cbdv.202570402

Hongwei Han, Zhongling Wen, Minkai Yang, Changyi Wang, Yudi Ma, Qingqing Chen, Dexing Jiang, Ye Xu, Aliya Fazal, Wencai Jie, Xiaoran Lv, Tongming Yin, Hongyan Lin, Guihua Lu, Jinliang Qi, Yonghua Yang, Guohua Xu

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引用次数: 0

摘要

覆盖特性。紫草素是一种从紫草中提取的萘醌类生物活性化合物，具有重要的药理作用。其衍生物M12在结直肠癌（CRC）中显示出有效的抗肿瘤作用。M12诱导CRC细胞凋亡是通过激活ros依赖的线粒体通路，同时抑制PI3K/AKT信号级联介导的。这些发现突出了M12作为治疗结直肠癌的有希望的治疗候选药物的潜力。更多细节可以在杨永华、徐国华及其同事的文章e202403291中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cover Feature: Shikonin Derivative Suppresses Colorectal Cancer Cells Growth via Reactive Oxygen Species-Mediated Mitochondrial Apoptosis and PI3K/AKT Pathway (Chem. Biodiversity 4/2025)

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Cover Feature: Shikonin Derivative Suppresses Colorectal Cancer Cells Growth via Reactive Oxygen Species-Mediated Mitochondrial Apoptosis and PI3K/AKT Pathway (Chem. Biodiversity 4/2025)

Cover Feature. Shikonin, a naphthoquinone bioactive compound derived from Lithospermum erythrorhizon, has demonstrated significant pharmacological properties. Its derivative, M12, exhibits potent antitumor effects in colorectal cancer (CRC). The induction of apoptosis by M12 in CRC cells is mediated through the activation of the ROS-dependent mitochondrial pathway, coupled with the suppression of the PI3K/AKT signaling cascade. These findings highlight the potential of M12 as a promising therapeutic candidate for the treatment of CRC. More details can be found in article number e202403291 by Yonghua Yang, Guohua Xu, and co-workers.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.