作为 CABG 术后长期预后因素的血浆致动脉粥样硬化指数 (AIP)：大型三级中心登记分析的启示

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports Pub Date : 2025-04-16 DOI:10.1002/hsr2.70616

Abolfazl Salari, Parvin Kalhor, Ahmad Vakili-Basir, Houshang Bavandpour Karvane, Mina Pashang, Mojgan Ghavami, Arash Jalali, Farshid Alaeddini, Farzad Masoudkabir

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引用次数: 0

摘要

背景与目的血浆动脉粥样硬化指数（AIP）在预测冠状动脉搭桥术（CABG）术后主要不良脑血管事件（MACCE）中的作用尚未得到充分探讨。本研究旨在探讨AIP在预测CABG后MACCE及其各组成部分的预后价值。方法：本研究是一项大规模回顾性研究，研究对象为接受孤立性冠脉搭桥的患者。主要结局为全因死亡率和MACCE，包括急性冠状动脉综合征（ACS）、脑血管意外(CVA)/短暂性缺血发作（TIA）、血运重建术和全因死亡率。在验证PH假设后，考虑稳定的逆概率权重（IPW），进行比例风险（PH） Cox回归。结果共分析了23432例患者，中位随访时间为111.4个月。加权所有变量后，较高的AIP与MACCE风险显著增加相关(HR = 1.05；95% ci: 1.01-1.09；p = 0.006)。此外，AIP是血运重建风险的重要预测因子(HR = 1.15；95% ci: 1.01-1.30；p = 0.034)和ACS (HR = 1.09；95% ci: 1.01-1.17；p = 0.020)。然而，AIP不能作为全因死亡率和CVA的预后因素。结论AIP预测冠脉搭桥后MACCE、血运重建和ACS，是一个容易获得的预后因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Atherogenic Index of Plasma (AIP) as a Long-Term Prognostic Factor Following CABG: Unveiling Insights From a Large-Scale Tertiary Center Registry Analysis

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Atherogenic Index of Plasma (AIP) as a Long-Term Prognostic Factor Following CABG: Unveiling Insights From a Large-Scale Tertiary Center Registry Analysis

Background and Aims

The role of the atherogenic index of plasma (AIP) in predicting major adverse cerebro-cardiovascular events (MACCE) after coronary artery bypass grafting (CABG) surgery has not been fully explored. The present study aims to investigate the prognostic value of AIP in predicting MACCE and its individual components following CABG.

Methods

This is a large-scale retrospective study conducted on patients who underwent isolated CABG. The primary outcomes were all-cause mortality and MACCE, which included acute coronary syndrome (ACS), Cerebrovascular accident (CVA)/transient ischemia attack (TIA), revascularization, and all-cause mortality. Proportional Hazard (PH) Cox regression, considering stabilized Inverse probability weightings (IPW), was conducted after verifying the PH assumption.

Results

Totally, 23,432 patients analyzed with median 111.4-month follow-up duration. After weighting all variables, a higher AIP was associated with a significantly increased risk of MACCE (HR = 1.05; 95% CI: 1.01–1.09; p = 0.006). Furthermore, AIP was a significant predictor of the risk of revascularization (HR = 1.15; 95% CI: 1.01–1.30; p = 0.034) and ACS (HR = 1.09; 95% CI: 1.01–1.17; p = 0.020). However, AIP couldn't be a prognostic factor for all-cause mortality and CVA.