A. Mohamed Adnan, Architha Vijayalakshmi, S. Hemalatha
{"title":"双酚A对斑马鱼胚胎的影响及红树林植物制剂的缓解","authors":"A. Mohamed Adnan, Architha Vijayalakshmi, S. Hemalatha","doi":"10.1007/s11270-025-08010-1","DOIUrl":null,"url":null,"abstract":"<div><p>Bisphenol A (BPA) is a widely used component in plastics, BPA leaches into food and water, under conditions with pH changes or increased temperatures. This current study focuses on the evaluation BPA induced developmental toxicity in zebrafish embryos. And estimation of mangrove <i>Avicennia marina</i> (AM) and <i>Avicennia officianalis</i> (AO) leaf extracts for their nullifying properties against BPA these embryos. BPA-induced detrimental effects on embryo pigmentation and mortality are concentrations and time-dependent. The lethal concentration 50 (LC50) value for BPA was determined as 12.5 µg/mL. Co-treatment studies with AM and AO extracts alongside BPA did not significantly nullify toxicity; however, AO showed delayed hatching and increased mortality rates compared to AM. The apoptotic assays showed the induction of neurotoxicity and reduced fluorescence in brain cells and nerves in BPA-exposed larvae. However, AM and AO extracts at 25 µg/mL showed significant protective effects in brain cells and spinal regions akin to control. AO demonstrated superior neuroprotective effects, highlighting its potential as a nullifying agent against BPA-induced neurodegeneration. Fungal stains used, showed significant reduction in BPA present in the solution, proving its BPA degrading capabilities. Future studies could explore the molecular mechanisms underlying these effects and optimize concentrations for enhanced nullification of BPA-induced toxicity.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":808,"journal":{"name":"Water, Air, & Soil Pollution","volume":"236 6","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Bisphenol A on Zebrafish Embryos and Mitigation Using Mangrove Botanicals\",\"authors\":\"A. Mohamed Adnan, Architha Vijayalakshmi, S. Hemalatha\",\"doi\":\"10.1007/s11270-025-08010-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Bisphenol A (BPA) is a widely used component in plastics, BPA leaches into food and water, under conditions with pH changes or increased temperatures. This current study focuses on the evaluation BPA induced developmental toxicity in zebrafish embryos. And estimation of mangrove <i>Avicennia marina</i> (AM) and <i>Avicennia officianalis</i> (AO) leaf extracts for their nullifying properties against BPA these embryos. BPA-induced detrimental effects on embryo pigmentation and mortality are concentrations and time-dependent. The lethal concentration 50 (LC50) value for BPA was determined as 12.5 µg/mL. Co-treatment studies with AM and AO extracts alongside BPA did not significantly nullify toxicity; however, AO showed delayed hatching and increased mortality rates compared to AM. The apoptotic assays showed the induction of neurotoxicity and reduced fluorescence in brain cells and nerves in BPA-exposed larvae. However, AM and AO extracts at 25 µg/mL showed significant protective effects in brain cells and spinal regions akin to control. AO demonstrated superior neuroprotective effects, highlighting its potential as a nullifying agent against BPA-induced neurodegeneration. Fungal stains used, showed significant reduction in BPA present in the solution, proving its BPA degrading capabilities. Future studies could explore the molecular mechanisms underlying these effects and optimize concentrations for enhanced nullification of BPA-induced toxicity.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":808,\"journal\":{\"name\":\"Water, Air, & Soil Pollution\",\"volume\":\"236 6\",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-04-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Water, Air, & Soil Pollution\",\"FirstCategoryId\":\"6\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11270-025-08010-1\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Water, Air, & Soil Pollution","FirstCategoryId":"6","ListUrlMain":"https://link.springer.com/article/10.1007/s11270-025-08010-1","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Impact of Bisphenol A on Zebrafish Embryos and Mitigation Using Mangrove Botanicals
Bisphenol A (BPA) is a widely used component in plastics, BPA leaches into food and water, under conditions with pH changes or increased temperatures. This current study focuses on the evaluation BPA induced developmental toxicity in zebrafish embryos. And estimation of mangrove Avicennia marina (AM) and Avicennia officianalis (AO) leaf extracts for their nullifying properties against BPA these embryos. BPA-induced detrimental effects on embryo pigmentation and mortality are concentrations and time-dependent. The lethal concentration 50 (LC50) value for BPA was determined as 12.5 µg/mL. Co-treatment studies with AM and AO extracts alongside BPA did not significantly nullify toxicity; however, AO showed delayed hatching and increased mortality rates compared to AM. The apoptotic assays showed the induction of neurotoxicity and reduced fluorescence in brain cells and nerves in BPA-exposed larvae. However, AM and AO extracts at 25 µg/mL showed significant protective effects in brain cells and spinal regions akin to control. AO demonstrated superior neuroprotective effects, highlighting its potential as a nullifying agent against BPA-induced neurodegeneration. Fungal stains used, showed significant reduction in BPA present in the solution, proving its BPA degrading capabilities. Future studies could explore the molecular mechanisms underlying these effects and optimize concentrations for enhanced nullification of BPA-induced toxicity.
期刊介绍：
Water, Air, & Soil Pollution is an international, interdisciplinary journal on all aspects of pollution and solutions to pollution in the biosphere. This includes chemical, physical and biological processes affecting flora, fauna, water, air and soil in relation to environmental pollution. Because of its scope, the subject areas are diverse and include all aspects of pollution sources, transport, deposition, accumulation, acid precipitation, atmospheric pollution, metals, aquatic pollution including marine pollution and ground water, waste water, pesticides, soil pollution, sewage, sediment pollution, forestry pollution, effects of pollutants on humans, vegetation, fish, aquatic species, micro-organisms, and animals, environmental and molecular toxicology applied to pollution research, biosensors, global and climate change, ecological implications of pollution and pollution models. Water, Air, & Soil Pollution also publishes manuscripts on novel methods used in the study of environmental pollutants, environmental toxicology, environmental biology, novel environmental engineering related to pollution, biodiversity as influenced by pollution, novel environmental biotechnology as applied to pollution (e.g. bioremediation), environmental modelling and biorestoration of polluted environments.
Articles should not be submitted that are of local interest only and do not advance international knowledge in environmental pollution and solutions to pollution. Articles that simply replicate known knowledge or techniques while researching a local pollution problem will normally be rejected without review. Submitted articles must have up-to-date references, employ the correct experimental replication and statistical analysis, where needed and contain a significant contribution to new knowledge. The publishing and editorial team sincerely appreciate your cooperation.
Water, Air, & Soil Pollution publishes research papers; review articles; mini-reviews; and book reviews.
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