β-氨基丙烯酰胺和丙二腈的正式[4+2]环化：取代吡啶-2(1H)- 1的合成路线

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Sciences Pub Date : 2025-04-17 DOI:10.1007/s12039-025-02360-3

Xin Liu, Jiawang Li, Rui Zhang, Dewen Dong

引用次数: 0

摘要

在碳酸钾（K2CO3）的存在下，在二甲基亚砜（DMSO）中，通过α-功能化β-氨基丙烯酰胺和丙二腈的形式[4+2]环形成了一种简便高效的多取代吡啶-2(1H)- 1的合成方法。图形抽象

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Formal [4+2] annulation of β-aminoacrylamides and malononitrile: a synthetic route to substituted pyridin-2(1H)-ones

A facile and efficient synthesis of polysubstituted pyridin-2(1H)-ones has been developed via a formal [4+2] annulation of readily available α-functionalized β-aminoacrylamides and malononitrile in the presence of potassium carbonate (K₂CO₃) in dimethylsulfoxide (DMSO).

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.