{"title":"以5-羟吡嗪-2-羧酸为配体的Cd（II）和Mn（II）配合物的合成、晶体结构和CT-DNA/BSA结合","authors":"Yanhong Yang, Rui Wang, Bing Li, Xiaoshuang Zhu, Jiawei Liang, Hongyan Wu, Shoufeng Fu, Jiaxing He, Xiaoyan Chen","doi":"10.1007/s11243-024-00610-w","DOIUrl":null,"url":null,"abstract":"<div><p>Due to the potential applications of bioactive compounds, two isomorphous mononuclear coordination polymers [M(pydc)(H<sub>2</sub>O)]<sub>n</sub> (M = Cd (<b>1</b>), Mn (<b>2</b>), H<sub>2</sub>pydc = 5-hydroxypyrazine-2-carboxylic acid) were synthesized and fully characterized by single-crystal X-ray diffraction, elemental analysis, thermogravimetric analysis, infrared spectroscopy, <sup>1</sup>H nuclear magnetic resonance spectroscopy, X-ray photoelectron spectroscopy and powder X-ray diffraction analysis. Complexes <b>1</b> and <b>2</b> are six-coordinated motifs and exhibit slightly deformed octahedral geometry, which extends into three-dimensional frame structures. Complexes <b>1</b> and <b>2</b> interact with calf thymus DNA (CT-DNA) through intercalation, hydrogen bonding and van der Waals forces. Both complexes had good binding propensity for bovine serum albumin (BSA) with a relatively high binding constant (10<sup>4</sup> L mol<sup>−1</sup>) superior to that of H<sub>2</sub>pydc (10<sup>3</sup> L mol<sup>−1</sup>). The interactions between H<sub>2</sub>pydc, complexes <b>1</b> and <b>2</b> and BSA were static quenching procedures. Site competition experiments showed that the ligands and complexes interact with BSA at site II.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"50 2","pages":"127 - 138"},"PeriodicalIF":1.6000,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, crystal structures and CT-DNA/BSA binding of Cd(II) and Mn(II) complexes with 5-hydroxypyrazine-2-carboxylic acid as a ligand\",\"authors\":\"Yanhong Yang, Rui Wang, Bing Li, Xiaoshuang Zhu, Jiawei Liang, Hongyan Wu, Shoufeng Fu, Jiaxing He, Xiaoyan Chen\",\"doi\":\"10.1007/s11243-024-00610-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Due to the potential applications of bioactive compounds, two isomorphous mononuclear coordination polymers [M(pydc)(H<sub>2</sub>O)]<sub>n</sub> (M = Cd (<b>1</b>), Mn (<b>2</b>), H<sub>2</sub>pydc = 5-hydroxypyrazine-2-carboxylic acid) were synthesized and fully characterized by single-crystal X-ray diffraction, elemental analysis, thermogravimetric analysis, infrared spectroscopy, <sup>1</sup>H nuclear magnetic resonance spectroscopy, X-ray photoelectron spectroscopy and powder X-ray diffraction analysis. Complexes <b>1</b> and <b>2</b> are six-coordinated motifs and exhibit slightly deformed octahedral geometry, which extends into three-dimensional frame structures. Complexes <b>1</b> and <b>2</b> interact with calf thymus DNA (CT-DNA) through intercalation, hydrogen bonding and van der Waals forces. Both complexes had good binding propensity for bovine serum albumin (BSA) with a relatively high binding constant (10<sup>4</sup> L mol<sup>−1</sup>) superior to that of H<sub>2</sub>pydc (10<sup>3</sup> L mol<sup>−1</sup>). The interactions between H<sub>2</sub>pydc, complexes <b>1</b> and <b>2</b> and BSA were static quenching procedures. Site competition experiments showed that the ligands and complexes interact with BSA at site II.</p></div>\",\"PeriodicalId\":803,\"journal\":{\"name\":\"Transition Metal Chemistry\",\"volume\":\"50 2\",\"pages\":\"127 - 138\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-10-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transition Metal Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11243-024-00610-w\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transition Metal Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11243-024-00610-w","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
摘要
由于生物活性化合物的潜在应用，合成了两种同形单核配位聚合物[M(pydc)(H2O)]n (M = Cd （1), Mn (2), H2pydc = 5-羟吡嗪-2-羧酸），并通过单晶x射线衍射、元素分析、热重分析、红外光谱、1H核磁共振波谱、x射线光电子能谱和粉末x射线衍射分析对其进行了全面表征。配合物1和2是六协调的基元，呈现出轻微变形的八面体几何，延伸成三维框架结构。配合物1和2通过嵌入、氢键和范德华力与小牛胸腺DNA （CT-DNA）相互作用。两种配合物对牛血清白蛋白（BSA）均具有良好的结合倾向，其结合常数（104 L mol−1）均高于H2pydc （103 L mol−1）。H2pydc、配合物1和2与BSA之间的相互作用是静态猝灭过程。位点竞争实验表明，配体和配合物在位点II与BSA相互作用。
Synthesis, crystal structures and CT-DNA/BSA binding of Cd(II) and Mn(II) complexes with 5-hydroxypyrazine-2-carboxylic acid as a ligand
Due to the potential applications of bioactive compounds, two isomorphous mononuclear coordination polymers [M(pydc)(H2O)]n (M = Cd (1), Mn (2), H2pydc = 5-hydroxypyrazine-2-carboxylic acid) were synthesized and fully characterized by single-crystal X-ray diffraction, elemental analysis, thermogravimetric analysis, infrared spectroscopy, 1H nuclear magnetic resonance spectroscopy, X-ray photoelectron spectroscopy and powder X-ray diffraction analysis. Complexes 1 and 2 are six-coordinated motifs and exhibit slightly deformed octahedral geometry, which extends into three-dimensional frame structures. Complexes 1 and 2 interact with calf thymus DNA (CT-DNA) through intercalation, hydrogen bonding and van der Waals forces. Both complexes had good binding propensity for bovine serum albumin (BSA) with a relatively high binding constant (104 L mol−1) superior to that of H2pydc (103 L mol−1). The interactions between H2pydc, complexes 1 and 2 and BSA were static quenching procedures. Site competition experiments showed that the ligands and complexes interact with BSA at site II.
期刊介绍：
Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc.
Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.
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