{"title":"炔的立体发散官能化：综述","authors":"Ranjay Shaw, Ashmita Singh, Ismail Althagafi, Ramendra Pratap and Dharmendra Kumar Yadav","doi":"10.1039/D5RA01579K","DOIUrl":null,"url":null,"abstract":"<p >Alkynes are central in crafting pharmaceuticals, agrochemicals, and materials owing to their reactivity and linear geometry. This review unveils cutting-edge advancements in the stereo-divergent functionalization of alkynes, transforming them into invaluable tools for synthesizing stereochemically defined alkenes and alkanes. The review highlights ground-breaking methodologies that achieve exceptional <em>E</em>- and <em>Z</em>-selectivity using innovative catalysts like cobalt, nickel, and palladium through hydrogenation, hydroboration, and hydrosilylation. Recent breakthroughs such as dual-catalytic systems and energy transfer catalysis enable unprecedented stereocontrol. Sustainable strategies including water as a hydrogen source and recyclable catalysts align with green chemistry principles, paving the way for eco-friendly synthesis. This synthesis of cutting-edge techniques and their applications inspire new avenues in synthetic chemistry, offering transformative tools for creating complex molecular architectures with precision and sustainability.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 16","pages":" 12202-12245"},"PeriodicalIF":3.9000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra01579k?page=search","citationCount":"0","resultStr":"{\"title\":\"The stereo-divergent functionalization of alkynes: a comprehensive review\",\"authors\":\"Ranjay Shaw, Ashmita Singh, Ismail Althagafi, Ramendra Pratap and Dharmendra Kumar Yadav\",\"doi\":\"10.1039/D5RA01579K\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Alkynes are central in crafting pharmaceuticals, agrochemicals, and materials owing to their reactivity and linear geometry. This review unveils cutting-edge advancements in the stereo-divergent functionalization of alkynes, transforming them into invaluable tools for synthesizing stereochemically defined alkenes and alkanes. The review highlights ground-breaking methodologies that achieve exceptional <em>E</em>- and <em>Z</em>-selectivity using innovative catalysts like cobalt, nickel, and palladium through hydrogenation, hydroboration, and hydrosilylation. Recent breakthroughs such as dual-catalytic systems and energy transfer catalysis enable unprecedented stereocontrol. Sustainable strategies including water as a hydrogen source and recyclable catalysts align with green chemistry principles, paving the way for eco-friendly synthesis. This synthesis of cutting-edge techniques and their applications inspire new avenues in synthetic chemistry, offering transformative tools for creating complex molecular architectures with precision and sustainability.</p>\",\"PeriodicalId\":102,\"journal\":{\"name\":\"RSC Advances\",\"volume\":\" 16\",\"pages\":\" 12202-12245\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-04-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d5ra01579k?page=search\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"RSC Advances\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/ra/d5ra01579k\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"RSC Advances","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/ra/d5ra01579k","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
The stereo-divergent functionalization of alkynes: a comprehensive review
Alkynes are central in crafting pharmaceuticals, agrochemicals, and materials owing to their reactivity and linear geometry. This review unveils cutting-edge advancements in the stereo-divergent functionalization of alkynes, transforming them into invaluable tools for synthesizing stereochemically defined alkenes and alkanes. The review highlights ground-breaking methodologies that achieve exceptional E- and Z-selectivity using innovative catalysts like cobalt, nickel, and palladium through hydrogenation, hydroboration, and hydrosilylation. Recent breakthroughs such as dual-catalytic systems and energy transfer catalysis enable unprecedented stereocontrol. Sustainable strategies including water as a hydrogen source and recyclable catalysts align with green chemistry principles, paving the way for eco-friendly synthesis. This synthesis of cutting-edge techniques and their applications inspire new avenues in synthetic chemistry, offering transformative tools for creating complex molecular architectures with precision and sustainability.
期刊介绍：
An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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