{"title":"神经创伤治疗的bigels综述:组织微环境对齐的结构见解","authors":"Botle Moswatsi, Gillian Dumsile Mahumane, Pradeep Kumar, Yahya Essop Choonara","doi":"10.1016/j.bioadv.2025.214315","DOIUrl":null,"url":null,"abstract":"<div><div>Neural injuries pose a significant clinical challenge due to the brain's limited regenerative capacity and the complexity of developing biomaterials that can provide mechanical support and localized therapeutic delivery. Conventional biomaterials such as hydrogels and electrospun scaffolds exhibit limitations, including suboptimal mechanical integrity and uncontrolled drug diffusion. Bigels, biphasic systems composed of interpenetrating hydrophilic and hydrophobic phases, offer tunable viscoelasticity, enhanced drug loading capacity, and structural adaptability, making them promising candidates for addressing the multifaceted requirements of neurotherapeutics applications. Despite their established applications in the transdermal application, the potential of bigels in neurotherapeutics remains underexplored. This review critically examines bigel formulation strategies, physicochemical characteristics, and neuroregenerative potential. Key analytical techniques, including oscillatory rheology, scanning electron microscopy, and Fourier-transform infrared spectroscopy, are explored to assess pore morphology, viscoelastic behavior, and molecular interactions. The role of bigels in neuronal survival, axonal regeneration, and neuroinflammation modulation is highlighted, alongside considerations for scalability, batch-to-batch reproducibility, and regulatory compliance under Good Manufacturing Practices (GMP). Future research should focus on optimizing biodegradation kinetics, neurotrophic factor release profiles, and preclinical validation in traumatic brain injury and spinal cord injury models. Advancing bigel technology could facilitate their clinical translation as neuroprotective scaffolds in regenerative medicine.</div></div>","PeriodicalId":51111,"journal":{"name":"Materials Science & Engineering C-Materials for Biological Applications","volume":"174 ","pages":"Article 214315"},"PeriodicalIF":6.0000,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A review of bigels for neurotrauma therapeutics: Structural insights for tissue microenvironment alignment\",\"authors\":\"Botle Moswatsi, Gillian Dumsile Mahumane, Pradeep Kumar, Yahya Essop Choonara\",\"doi\":\"10.1016/j.bioadv.2025.214315\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Neural injuries pose a significant clinical challenge due to the brain's limited regenerative capacity and the complexity of developing biomaterials that can provide mechanical support and localized therapeutic delivery. Conventional biomaterials such as hydrogels and electrospun scaffolds exhibit limitations, including suboptimal mechanical integrity and uncontrolled drug diffusion. Bigels, biphasic systems composed of interpenetrating hydrophilic and hydrophobic phases, offer tunable viscoelasticity, enhanced drug loading capacity, and structural adaptability, making them promising candidates for addressing the multifaceted requirements of neurotherapeutics applications. Despite their established applications in the transdermal application, the potential of bigels in neurotherapeutics remains underexplored. This review critically examines bigel formulation strategies, physicochemical characteristics, and neuroregenerative potential. Key analytical techniques, including oscillatory rheology, scanning electron microscopy, and Fourier-transform infrared spectroscopy, are explored to assess pore morphology, viscoelastic behavior, and molecular interactions. The role of bigels in neuronal survival, axonal regeneration, and neuroinflammation modulation is highlighted, alongside considerations for scalability, batch-to-batch reproducibility, and regulatory compliance under Good Manufacturing Practices (GMP). Future research should focus on optimizing biodegradation kinetics, neurotrophic factor release profiles, and preclinical validation in traumatic brain injury and spinal cord injury models. Advancing bigel technology could facilitate their clinical translation as neuroprotective scaffolds in regenerative medicine.</div></div>\",\"PeriodicalId\":51111,\"journal\":{\"name\":\"Materials Science & Engineering C-Materials for Biological Applications\",\"volume\":\"174 \",\"pages\":\"Article 214315\"},\"PeriodicalIF\":6.0000,\"publicationDate\":\"2025-04-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Science & Engineering C-Materials for Biological Applications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772950825001426\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Science & Engineering C-Materials for Biological Applications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772950825001426","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
A review of bigels for neurotrauma therapeutics: Structural insights for tissue microenvironment alignment
Neural injuries pose a significant clinical challenge due to the brain's limited regenerative capacity and the complexity of developing biomaterials that can provide mechanical support and localized therapeutic delivery. Conventional biomaterials such as hydrogels and electrospun scaffolds exhibit limitations, including suboptimal mechanical integrity and uncontrolled drug diffusion. Bigels, biphasic systems composed of interpenetrating hydrophilic and hydrophobic phases, offer tunable viscoelasticity, enhanced drug loading capacity, and structural adaptability, making them promising candidates for addressing the multifaceted requirements of neurotherapeutics applications. Despite their established applications in the transdermal application, the potential of bigels in neurotherapeutics remains underexplored. This review critically examines bigel formulation strategies, physicochemical characteristics, and neuroregenerative potential. Key analytical techniques, including oscillatory rheology, scanning electron microscopy, and Fourier-transform infrared spectroscopy, are explored to assess pore morphology, viscoelastic behavior, and molecular interactions. The role of bigels in neuronal survival, axonal regeneration, and neuroinflammation modulation is highlighted, alongside considerations for scalability, batch-to-batch reproducibility, and regulatory compliance under Good Manufacturing Practices (GMP). Future research should focus on optimizing biodegradation kinetics, neurotrophic factor release profiles, and preclinical validation in traumatic brain injury and spinal cord injury models. Advancing bigel technology could facilitate their clinical translation as neuroprotective scaffolds in regenerative medicine.
期刊介绍:
Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include:
• Bioinspired and biomimetic materials for medical applications
• Materials of biological origin for medical applications
• Materials for "active" medical applications
• Self-assembling and self-healing materials for medical applications
• "Smart" (i.e., stimulus-response) materials for medical applications
• Ceramic, metallic, polymeric, and composite materials for medical applications
• Materials for in vivo sensing
• Materials for in vivo imaging
• Materials for delivery of pharmacologic agents and vaccines
• Novel approaches for characterizing and modeling materials for medical applications
Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources.
Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!