抗mda5抗体阳性皮肌炎患者诱导多能干细胞（iPSC）系（inndsu0010 - a）的生成

IF 0.8 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2025-04-15 DOI:10.1016/j.scr.2025.103714

Chen Zhang , Shaoshuai Liang , Bing Zhao , Qingsong Fu , Fengyi Zhang , Xiaotian Ma , Didi Shan , Hongxu Wang , Jianing Li , Ping Sun , Yu Wang , Guoyong Zhang , Ying Hou , Tingjun Dai , Fuchen Liu , Chuanzhu Yan , Kai Shao

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引用次数: 0

摘要

抗黑色素瘤分化相关蛋白5 （MDA5）抗体阳性的皮肌炎（MDA5- dm）是皮肌炎的一种亚型，可能由病毒感染引发（Lu et al., 2024）。我们从MDA5-DM患者的皮肤成纤维细胞中生成并鉴定了一种人诱导多能干细胞（hiPSC）系。它们的多能性通过在RNA和蛋白质水平上表达多个多能性标记以及向所有三种胚层分化的能力得到证实。

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Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi0010-A) from a patient with Anti-MDA5 antibody-positive dermatomyositis

Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of dermatomyositis, potentially triggered by viral infection (Lu et al., 2024). We generated and characterized a human induced pluripotent stem cell (hiPSC) line from skin fibroblasts of a patient with MDA5-DM. Their pluripotency was demonstrated by the expression of multiple pluripotency markers on the RNA and protein levels, as well as their ability to differentiate into all three germ layers.

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来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.