利用蒙特卡罗模拟研究靶区表面曲率对外束放射治疗剂量学特性的影响

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2025-04-15 DOI:10.1016/j.radphyschem.2025.112828

Mohammed Rezzoug , Mustapha Zerfaoui , Yassine Oulhouq , Abdeslem Rrhioua , Samir Didi , Dikra Bakari

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引用次数: 0

摘要

目的利用GATE （Geant4 Application for tomography Emission）蒙特卡罗模拟工具，探讨靶区表面曲率对外束放射治疗剂量学特性的影响。材料和方法本研究利用PRIMO平台（一个免费的蒙特卡罗模拟软件，用于放射治疗中的线性加速器和剂量计算）的相空间数据（Phsp）验证了VARIAN Clinac 2100C加速器的模拟模型。关于数以百万计的粒子（光子、电子和正电子）的能量、位置、方向和其他特征的信息都包含在Phsp中，这对于精确的蒙特卡罗模拟至关重要。对于不同的场大小和应用尺寸，6毫伏光子束以及6兆电子伏，9兆电子伏和12兆电子伏电子束是感兴趣的。为了验证，用伽马指数（2% / 2mm）测量的数据与GATE蒙特卡罗模拟进行了比较。弯曲的表面水箱也被用来检验表面曲率如何影响剂量分布。结果研究发现，表面曲率对深度屈服曲线和剂量分布有影响，而表面曲率受场大小、能量和曲率程度的控制。在深度-百分比（PDD）剂量曲线中，这种效应对光子的影响很小，但对超过积聚区域的电子则很明显，这使得曲率最大的深度处的剂量增加。根据剂量谱图，在弯曲介质中电子分布曲线发生了变化，表明曲率的影响来自远离束场中心的区域。根据场的大小和能量，当场的横向尺寸大于曲率半径（2xR）的两倍时，特别是在6 MeV时，这种位移在半影区域变得重要。结论外束放射治疗中，表面曲率对电子束和光子束的剂量学特性有显著影响。电子束的影响更为明显。

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Investigating the impact of target area surface curvature on dosimetric characteristics of external beam radiation therapy using Monte Carlo simulation

Purpose

The purpose of this investigation was to access the impact of target area surface curvature on the dosimetric characteristics in external beam radiation therapy using the GATE (Geant4 Application for Tomographic Emission) Monte Carlo simulation tool.

Materials and methods

The study validated a simulation model using phase-space data (Phsp) from the PRIMO platform (a free Monte Carlo-based simulation software for linear accelerators and dose calculations in radiotherapy) for the VARIAN Clinac 2100C accelerator. Information on the energy, position, direction, and other characteristics of millions of particles (photons, electrons, and positrons) is contained in the Phsp which is crucial for accurate Monte Carlo simulations. For different field sizes and applicator dimensions, 6 MV photon beams as well as 6 MeV, 9 MeV, and 12 MeV electron beams are of interest. For validation, data measured with the gamma index (2 %/2 mm) was compared to the GATE Monte Carlo simulations. Curved surface water tanks were also used to examine how surface curvature affected dose distributions.

Results

The study found that surface curvature, which is controlled by field size, energy, and degree of curvature, has an impact on depth yield curves and dose profiles. The effect is small for photons but evident for electrons beyond the buildup region in depth-percentage (PDD) dose curves, which raises the dose at depth for the biggest curvature. The electron profile curves changed in the curved mediums, indicating that the curvature impacts from areas farther from the center of the beam field, according to the dose profiles. Depending on the field's size and energy, this shift becomes important in the penumbra area when the field's lateral size is greater than twice the radius of curvature (2xR), especially at 6 MeV.

Conclusions

Surface curvature has a notable impact on the dosimetric characteristics of electron and photon beams in external beam radiation therapy. The effects are more pronounced for electron beams.

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.