角化细胞中的桥粒突变促进黑色素瘤的发展

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2025-04-16 DOI:10.1038/s41588-025-02133-1

Patricia A. Possik, Kerrie L. Marie, David J. Adams

引用次数: 0

摘要

这项研究发现，角质形成细胞中脱模体基因的体细胞突变支持黑色素瘤的生长。这项研究对我们了解癌症的体细胞结构具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Desmosome mutations in keratinocytes fuel melanoma development

查看原文本刊更多论文

Desmosome mutations in keratinocytes fuel melanoma development

In this study, somatic mutations in desmosome genes of keratinocytes were found to support melanoma growth. This work has fundamental implications for our understanding of the somatic landscape of cancer.

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution