双整合素靶向超分子肽纳米结构用于增强肝脏输送和抗纤维化治疗（小15/2025）

IF 12.1 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2025-04-16 DOI:10.1002/smll.202570115

Bowen Li, Jianwei Bao, Yan Huang, Jikang Liu, Xuehai Yan, Qianli Zou

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引用次数: 0

摘要

通过α5β1和αvβ3双整合素结合基序，合理设计自组装肽，形成能够包封大黄酸的纳米颗粒。基于多靶点和治疗模块的组合，所得到的肽-大黄酸纳米结构具有改善肝脏递送和增强抗纤维化治疗效果的特点，展示了一种有前景的肝纤维化治疗策略。文章编号2409038，黄燕，闫雪海，邹倩丽和同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Dual-Integrin-Targeted Supramolecular Peptide Nanoarchitectonics for Enhanced Hepatic Delivery and Antifibrotic Therapy (Small 15/2025)

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Dual-Integrin-Targeted Supramolecular Peptide Nanoarchitectonics for Enhanced Hepatic Delivery and Antifibrotic Therapy (Small 15/2025)

Peptide Nanoarchitectonics

A rationally designed self-assembling peptide, featuring dual integrin-binding motifs for α5β1 and αvβ3, forms nanoparticles capable of encapsulating rhein. The resulted peptide-rhein nanoarchitectonics exhibit improved hepatic delivery and enhanced antifibrotic therapeutic effects based on the combination of multiple targets and therapeutic modules, demonstrating a promising strategy for hepatic fibrosis therapy. More in article number 2409038, Yan Huang, Xuehai Yan, Qianli Zou, and co-workers.

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.