1,3-炔、NBS和TMSN3三组分级联环法制备溴取代2h -吡咯和3h -吡咯

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2025-02-19 DOI:10.1002/cjoc.202401260

Zhen Zhang, Qingting Song, Fan Qin, Han Yue, Xiaoyu Xie, Lei Wang, Tao Miao

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引用次数: 0

摘要

以1,3-炔、NBS和TMSN3为原料，通过水促进的环化反应或tfa催化的环化/2,3移位反应，实现了一种新的、高效的选择性合成溴取代2h -吡咯和3h -吡咯的方法，在温和的条件下，以中高收率提供了一系列结构多样的产品。

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Selective Synthesis of Bromo-substituted 2H-Pyrroles and 3H-Pyrroles via Three-Component Cascade Annulation of 1,3-Enynes, NBS and TMSN3

A novel and efficient method for selective synthesis of bromo-substituted 2H-pyrroles and 3H-pyrroles has been achieved from 1,3-enynes, NBS and TMSN₃ via H₂O-promoted cyclization reactions or TFA-catalyzed cyclization/2,3-shift reactions, providing a range of structurally diverse products in moderate to good yields under mild conditions.

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.