{"title":"系统性硬化症患者的益生菌干预：系统回顾和未来展望","authors":"Zahra Mirfeizi, Mahmoud Mahmoudi, Marzieh Monemi, Amin Tajerian, Arezoo Faridzadeh","doi":"10.1002/hsr2.70657","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background and Aims</h3>\n \n <p>Systemic sclerosis (SSc) is an uncommon autoimmune connective tissue disease distinguished by fibrosis and vascular abnormalities, often leading to gastrointestinal problems. This review explores the potential of probiotics in managing SSc-related gastrointestinal issues and modulating immune responses, highlighting the need for innovative treatments to improve patient well-being.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We performed an extensive literature search up to October 2023 in databases, including Web of Science, PubMed/MEDLINE, and Scopus.</p>\n </section>\n \n <section>\n \n <h3> Result</h3>\n \n <p>This review detected four articles that investigated the impact of probiotics on SSc. These studies, comprising non-randomized observational studies and randomized clinical trials, provide preliminary insights suggesting that probiotics may be efficacious in modulating the immune response and, consequently, in improving gastrointestinal symptoms in SSc patients.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The comprehensive review suggests that probiotics may aid in managing gastrointestinal symptoms and modulating immune responses in SSc. However, it is essential to acknowledge the limited existing evidence, underscoring the need for more rigorous randomized controlled trials to thoroughly assess their effectiveness.</p>\n </section>\n </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70657","citationCount":"0","resultStr":"{\"title\":\"Probiotic Interventions in Systemic Sclerosis Patients: A Systematic Review and Future Prospects\",\"authors\":\"Zahra Mirfeizi, Mahmoud Mahmoudi, Marzieh Monemi, Amin Tajerian, Arezoo Faridzadeh\",\"doi\":\"10.1002/hsr2.70657\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background and Aims</h3>\\n \\n <p>Systemic sclerosis (SSc) is an uncommon autoimmune connective tissue disease distinguished by fibrosis and vascular abnormalities, often leading to gastrointestinal problems. This review explores the potential of probiotics in managing SSc-related gastrointestinal issues and modulating immune responses, highlighting the need for innovative treatments to improve patient well-being.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We performed an extensive literature search up to October 2023 in databases, including Web of Science, PubMed/MEDLINE, and Scopus.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Result</h3>\\n \\n <p>This review detected four articles that investigated the impact of probiotics on SSc. These studies, comprising non-randomized observational studies and randomized clinical trials, provide preliminary insights suggesting that probiotics may be efficacious in modulating the immune response and, consequently, in improving gastrointestinal symptoms in SSc patients.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The comprehensive review suggests that probiotics may aid in managing gastrointestinal symptoms and modulating immune responses in SSc. However, it is essential to acknowledge the limited existing evidence, underscoring the need for more rigorous randomized controlled trials to thoroughly assess their effectiveness.</p>\\n </section>\\n </div>\",\"PeriodicalId\":36518,\"journal\":{\"name\":\"Health Science Reports\",\"volume\":\"8 4\",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-04-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70657\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Health Science Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/hsr2.70657\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health Science Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hsr2.70657","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
背景和目的系统性硬化症（SSc）是一种罕见的自身免疫性结缔组织疾病，以纤维化和血管异常为特征，常导致胃肠道问题。这篇综述探讨了益生菌在管理ssc相关胃肠道问题和调节免疫反应方面的潜力，强调了创新治疗方法以改善患者健康的必要性。方法在截至2023年10月的Web of Science、PubMed/MEDLINE、Scopus等数据库中进行广泛的文献检索。结果本综述发现了4篇研究益生菌对SSc影响的文章。这些研究包括非随机观察性研究和随机临床试验，提供了初步的见解，表明益生菌可能有效调节免疫反应，从而改善SSc患者的胃肠道症状。结论综上所述，益生菌可能有助于控制SSc的胃肠道症状和调节免疫反应。然而，必须承认有限的现有证据，强调需要更严格的随机对照试验来彻底评估其有效性。
Probiotic Interventions in Systemic Sclerosis Patients: A Systematic Review and Future Prospects
Background and Aims
Systemic sclerosis (SSc) is an uncommon autoimmune connective tissue disease distinguished by fibrosis and vascular abnormalities, often leading to gastrointestinal problems. This review explores the potential of probiotics in managing SSc-related gastrointestinal issues and modulating immune responses, highlighting the need for innovative treatments to improve patient well-being.
Methods
We performed an extensive literature search up to October 2023 in databases, including Web of Science, PubMed/MEDLINE, and Scopus.
Result
This review detected four articles that investigated the impact of probiotics on SSc. These studies, comprising non-randomized observational studies and randomized clinical trials, provide preliminary insights suggesting that probiotics may be efficacious in modulating the immune response and, consequently, in improving gastrointestinal symptoms in SSc patients.
Conclusion
The comprehensive review suggests that probiotics may aid in managing gastrointestinal symptoms and modulating immune responses in SSc. However, it is essential to acknowledge the limited existing evidence, underscoring the need for more rigorous randomized controlled trials to thoroughly assess their effectiveness.
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