Mohammed Y. Alessa, Jawad S. Alnajjar, Mohammed A. Almarzooq, Mohammed A. AlSharit, Sarah Talal AlFares, Ahmed E. Alamin, Zuhair Yousef Aljomeah, Loai S. Albinsaad
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This condition can present with fever, nausea, right upper quadrant pain, and tenderness, influenced by various risk factors including age, gender, genetics, obesity, diet, and lifestyle.</p>\n </section>\n \n <section>\n \n <h3> Aim</h3>\n \n <p>This retrospective case-control study investigates the relationship between liver enzymes and acute cholecystitis in patients diagnosed based on Tokyo criteria in Alahsa, Saudi Arabia, from April 2016 to December 2023.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The study included 504 participants, with 249 cases of acute cholecystitis and 255 controls without cholecystitis, collected from King Fahad Hospital's medical records. Inclusion criteria were patients above 18 years old diagnosed with acute cholecystitis and availability of liver enzyme data. Data were analysed using SPSS version 21, employing descriptive analysis, Pearson Chi-Square test, Kruskal-Wallis test, box-plot visualization, Spearman correlation analysis, and ROC curve analysis.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The mean age was similar between cases (39.9 ± 15.3 years) and controls (40.1 ± 13.9 years). Significant differences were found in gender distribution and BMI. ALT and ALP levels were significantly higher in cases compared to controls (<i>p</i> = 0.002 and <i>p</i> = 0.001, respectively). The WBC count was also significantly higher in cases (<i>p</i> = 0.001). ROC curve analysis indicated that ALT and ALP had good discriminant ability to predict acute cholecystitis. Multiple hierarchical logistic regression showed that higher levels of ALT and ALP were significant predictors for acute cholecystitis, with adjusted odds ratios of 1.21 and 1.24, respectively.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Elevated ALT and ALP levels are significant predictors of acute cholecystitis, demonstrating the importance of liver enzymes in the diagnosis and management of this condition. The findings suggest that integrating liver enzyme measurements with Tokyo criteria can enhance diagnostic accuracy and improve healthcare outcomes for patients with acute cholecystitis.</p>\n </section>\n </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 4","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70707","citationCount":"0","resultStr":"{\"title\":\"The Association of Liver Enzymes With Acute Cholecystitis Diagnosed Using the Tokyo Criteria in the Eastern Region of Saudi Arabia: A Retrospective Case-Control Study\",\"authors\":\"Mohammed Y. Alessa, Jawad S. Alnajjar, Mohammed A. Almarzooq, Mohammed A. AlSharit, Sarah Talal AlFares, Ahmed E. Alamin, Zuhair Yousef Aljomeah, Loai S. Albinsaad\",\"doi\":\"10.1002/hsr2.70707\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Acute cholecystitis, an inflammation of the gallbladder, is often triggered by gallstones but can also result from ischemia, motility issues, chemical harm, and microbial infections. This condition can present with fever, nausea, right upper quadrant pain, and tenderness, influenced by various risk factors including age, gender, genetics, obesity, diet, and lifestyle.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>This retrospective case-control study investigates the relationship between liver enzymes and acute cholecystitis in patients diagnosed based on Tokyo criteria in Alahsa, Saudi Arabia, from April 2016 to December 2023.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The study included 504 participants, with 249 cases of acute cholecystitis and 255 controls without cholecystitis, collected from King Fahad Hospital's medical records. Inclusion criteria were patients above 18 years old diagnosed with acute cholecystitis and availability of liver enzyme data. Data were analysed using SPSS version 21, employing descriptive analysis, Pearson Chi-Square test, Kruskal-Wallis test, box-plot visualization, Spearman correlation analysis, and ROC curve analysis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The mean age was similar between cases (39.9 ± 15.3 years) and controls (40.1 ± 13.9 years). Significant differences were found in gender distribution and BMI. ALT and ALP levels were significantly higher in cases compared to controls (<i>p</i> = 0.002 and <i>p</i> = 0.001, respectively). The WBC count was also significantly higher in cases (<i>p</i> = 0.001). ROC curve analysis indicated that ALT and ALP had good discriminant ability to predict acute cholecystitis. 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The findings suggest that integrating liver enzyme measurements with Tokyo criteria can enhance diagnostic accuracy and improve healthcare outcomes for patients with acute cholecystitis.</p>\\n </section>\\n </div>\",\"PeriodicalId\":36518,\"journal\":{\"name\":\"Health Science Reports\",\"volume\":\"8 4\",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-04-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.70707\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Health Science Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/hsr2.70707\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health Science Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hsr2.70707","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
背景 急性胆囊炎是胆囊的一种炎症，通常由胆结石引发，但也可能由缺血、运动问题、化学伤害和微生物感染引起。这种疾病可表现为发热、恶心、右上腹疼痛和压痛，受年龄、性别、遗传、肥胖、饮食和生活方式等各种风险因素的影响。 目的 本回顾性病例对照研究调查了 2016 年 4 月至 2023 年 12 月期间沙特阿拉伯阿拉萨根据东京标准确诊的患者肝酶与急性胆囊炎之间的关系。 方法 该研究包括 504 名参与者，其中 249 例为急性胆囊炎患者，255 例为无胆囊炎的对照组，这些数据均来自法赫德国王医院的病历。纳入标准为 18 岁以上确诊为急性胆囊炎的患者，并提供肝酶数据。数据采用 SPSS 21 版进行分析，包括描述性分析、Pearson Chi-Square 检验、Kruskal-Wallis 检验、箱形图可视化、Spearman 相关性分析和 ROC 曲线分析。 结果 病例（39.9 ± 15.3 岁）和对照组（40.1 ± 13.9 岁）的平均年龄相似。性别分布和体重指数存在显著差异。病例的 ALT 和 ALP 水平明显高于对照组（分别为 p = 0.002 和 p = 0.001）。病例的白细胞计数也明显高于对照组（p = 0.001）。ROC 曲线分析表明，ALT 和 ALP 在预测急性胆囊炎方面具有良好的判别能力。多元层次逻辑回归显示，ALT 和 ALP 水平较高是急性胆囊炎的重要预测指标，调整后的几率分别为 1.21 和 1.24。 结论 ALT 和 ALP 水平升高可显著预测急性胆囊炎，这表明肝酶在诊断和治疗急性胆囊炎中的重要性。研究结果表明，将肝酶测定与东京标准相结合可提高诊断准确性，改善急性胆囊炎患者的医疗效果。
The Association of Liver Enzymes With Acute Cholecystitis Diagnosed Using the Tokyo Criteria in the Eastern Region of Saudi Arabia: A Retrospective Case-Control Study
Background
Acute cholecystitis, an inflammation of the gallbladder, is often triggered by gallstones but can also result from ischemia, motility issues, chemical harm, and microbial infections. This condition can present with fever, nausea, right upper quadrant pain, and tenderness, influenced by various risk factors including age, gender, genetics, obesity, diet, and lifestyle.
Aim
This retrospective case-control study investigates the relationship between liver enzymes and acute cholecystitis in patients diagnosed based on Tokyo criteria in Alahsa, Saudi Arabia, from April 2016 to December 2023.
Methods
The study included 504 participants, with 249 cases of acute cholecystitis and 255 controls without cholecystitis, collected from King Fahad Hospital's medical records. Inclusion criteria were patients above 18 years old diagnosed with acute cholecystitis and availability of liver enzyme data. Data were analysed using SPSS version 21, employing descriptive analysis, Pearson Chi-Square test, Kruskal-Wallis test, box-plot visualization, Spearman correlation analysis, and ROC curve analysis.
Results
The mean age was similar between cases (39.9 ± 15.3 years) and controls (40.1 ± 13.9 years). Significant differences were found in gender distribution and BMI. ALT and ALP levels were significantly higher in cases compared to controls (p = 0.002 and p = 0.001, respectively). The WBC count was also significantly higher in cases (p = 0.001). ROC curve analysis indicated that ALT and ALP had good discriminant ability to predict acute cholecystitis. Multiple hierarchical logistic regression showed that higher levels of ALT and ALP were significant predictors for acute cholecystitis, with adjusted odds ratios of 1.21 and 1.24, respectively.
Conclusion
Elevated ALT and ALP levels are significant predictors of acute cholecystitis, demonstrating the importance of liver enzymes in the diagnosis and management of this condition. The findings suggest that integrating liver enzyme measurements with Tokyo criteria can enhance diagnostic accuracy and improve healthcare outcomes for patients with acute cholecystitis.
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