封面：硒(II) -氮交换（SeNEx）化学和铜催化叠氮化物-炔环加成（CuAAC）的多组分反应

IF 16.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-04-16 DOI:10.1002/anie.202581662

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引用次数: 0

摘要

硒-氮交换（SeNEx）化学已与CuAAC无缝集成。侯伟、周伟、徐洪涛等人在他们的研究论文（e202500942）中报道了一种涉及苯并硒化唑酮类、炔类和叠氮化物的新型三组分反应。该反应通过独特的SeNEx-CuAAC串联途径进行，提供了高原子经济性的区域选择性地获得各种1,4,5-三取代的5-硒-1,2,3-三唑。通过靶向筛选，成功鉴定出一种有效的大肠杆菌β-葡萄糖醛酸酶抑制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Frontispiece: Multicomponent Reaction Integrating Selenium(II)–Nitrogen Exchange (SeNEx) Chemistry and Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC)

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Frontispiece: Multicomponent Reaction Integrating Selenium(II)–Nitrogen Exchange (SeNEx) Chemistry and Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC)

Selenium-nitrogen exchange (SeNEx) chemistry has been seamlessly integrated with CuAAC. In their Research Article (e202500942), Wei Hou, Wei Zhou, Hongtao Xu et al. report a novel three-component reaction involving benzoselenazolones, alkynes, and azides. This reaction proceeds via a unique SeNEx–CuAAC tandem pathway, providing direct access to diverse 1,4,5-trisubstituted 5-seleno-1,2,3-triazoles regioselectively with high atom economy. It was applied to successfully identify a potent Escherichia coli β-glucuronidase inhibitor through target-based screening.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.