钯催化邻烯基碘苯羰基化合成3-芳烯二酮

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2025-02-14 DOI:10.1002/cjoc.202401269

Minxiu Qian, Lingyun Yao, Zhi Li, Xusheng Shao, Quannan Wang, Wei-Ping Deng

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引用次数: 0

摘要

我们开发了一种新型钯催化的碘苯邻烯烃与 CO 的羰基化反应，以良好到极佳的收率（收率高达 94%）获得了多种 3-芳基茚酮。该方法具有广泛的底物范围和良好的官能团兼容性。通过克级规模的反应、多种产品衍生以及 PPARγ 激动剂中间体的制备，证明了该合成方法的实用性。

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Palladium-Catalyzed Carbonylation of ortho-Alkenyl Iodobenzenes for the Construction of 3-Arylindenones

We developed a novel Pd-catalyzed carbonylation of ortho-alkenyl iodobenzenes with CO, affording a diverse array of 3-arylindenones in good to excellent yields (up to 94% yield). This methodology exhibits broad substrate scope and good functional group compatibility. The synthetic utility was demonstrated by a gram-scale reaction, diverse product derivatizations, and the preparation of an intermediate for a PPARγ agonist.

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.