沙比利/缬沙坦对心力衰竭患者室上性和室性心律失常的影响

IF 1.1 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Alireza Arzhangzadeh, Mohammad Hossein Nikoo, Majid Haghjoo, Fatemeh Rasekh, Shayan Shojaei, Asma Mousavi, Salma Nozhat, Roozbeh Narimani-Javid, Helia Bazroodi, Sana Neisi, Mitra Mojibpour, Mohammad Abedini, Saghi Eslamzadeh, Hamed Bazrafshan Drissi, Sasan Shafiei
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引用次数: 0

摘要

背景:心力衰竭伴射血分数降低(HFrEF)患者经常出现电干扰,如心室或心房颤动(AF)。Sacubitril/缬沙坦(SV)治疗与较低的死亡率、室性心动过速(VT)和心室颤动(VF)有关,并降低了对植入式心律转复除颤器(ICD)治疗的依赖。然而,关于SV在ICD或心脏再同步化除颤器(CRT-D)患者中的抗心律失常作用的研究有限。本研究旨在评估SV治疗对使用ICD或CRT-D装置的HFrEF患者抗心律失常起搏、除颤休克发生率和室性心律失常负担的影响。方法本研究在一家HF门诊进行,研究对象为接受SV治疗的HFrEF患者。主要结局包括VT、VF、非持续性VT (NsVT)、室上性心动过速(SVT)的发生率,以及相关干预措施,如抗心律失常起搏(ATP)和除颤休克。结果共有181例HFrEF患者完成了至少12个月的随访,平均年龄63.39±12岁;36.5%为男性,60.8%患有ICD。设备询问显示,VF事件显著减少(7比15,p = 0.025), VT和VF的综合结果显著减少(17比24,p = 0.047)。在开始SV治疗后,对ATP和电击等ICD干预的需求也显著减少(10比24,p = 0.012)。结论SV治疗可显著降低心律失常,尤其是室性心动过速和室性心动过速的发生率,同时减少与植入器械相关的临床干预需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Effect of Sacubitril/Valsartan on Supraventricular and Ventricular Arrhythmias in Patients With Heart Failure

The Effect of Sacubitril/Valsartan on Supraventricular and Ventricular Arrhythmias in Patients With Heart Failure

Background

Patients with heart failure with reduced ejection fraction (HFrEF) frequently experience electrical disturbances, such as ventricular or atrial fibrillation (AF). Sacubitril/Valsartan (SV) therapy has been linked to lower rates of mortality, ventricular tachycardia (VT), and ventricular fibrillation (VF), with decreased reliance on implantable cardioverter-defibrillator (ICD) therapy. However, studies on the antiarrhythmic effects of SV in patients with ICD or cardiac resynchronization therapy defibrillator (CRT-D) devices are limited. This study aimed to evaluate the impact of SV therapy on antiarrhythmic pacing, defibrillation shock occurrences, and the burden of ventricular arrhythmias in patients with HFrEF who have ICD or CRT-D devices.

Method

This study was conducted at a HF outpatient clinic involving patients with HFrEF treated with SV. Primary outcomes included the incidence of VT, VF, non-sustained VT (NsVT), supraventricular tachycardia (SVT), and related interventions such as antiarrhythmic pacing (ATP) and defibrillation shocks.

Result

A total of 181 HFrEF patients completed at least 12 months of follow-up, with a mean age of 63.39 ± 12 years; 36.5% were male, and 60.8% had an ICD. Device interrogation revealed a significant reduction in VF incidents (7 vs. 15, p = 0.025) and a decrease in the combined outcome of VT and VF (17 vs. 24, p = 0.047). The need for ICD interventions such as ATP and shocks also significantly decreased following the initiation of SV therapy (10 vs. 24, p = 0.012).

Conclusion

SV therapy significantly reduces the incidence of cardiac arrhythmias, particularly VT and VF, while decreasing the need for clinical interventions related to implanted devices.

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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
88
审稿时长
6-12 weeks
期刊介绍: The ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (A.N.E) is an online only journal that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. ANE is the first journal in an evolving subspecialty that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. The publication includes topics related to 12-lead, exercise and high-resolution electrocardiography, arrhythmias, ischemia, repolarization phenomena, heart rate variability, circadian rhythms, bioengineering technology, signal-averaged ECGs, T-wave alternans and automatic external defibrillation. ANE publishes peer-reviewed articles of interest to clinicians and researchers in the field of noninvasive electrocardiology. Original research, clinical studies, state-of-the-art reviews, case reports, technical notes, and letters to the editors will be published to meet future demands in this field.
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