Traffic flow and signals: Regulating the movement within cells

Intracellular trafficking is known to regulate the outcomes of cellular signalling, with its role in signal generation, reception and interpretation well appreciated. Trafficking within cells can control ligand release, generate and maintain morphogen gradients, regulate ligand uptake within a cell and integrate multiple signals that ultimately result in altered gene expression. This process is especially important over the course of development of multicellular organisms wherein signals within a developing embryo result in the generation of specialized cells.

In this review, we discuss recent developments in our understanding of how intracellular trafficking modulates signalling output and ultimately, cellular identity and highlight recent findings that help us advance our understanding of how the cross talk between trafficking and cell signalling dictates cell fate.