6-17岁儿童血液微量金属与贫血的关系

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-04-12 DOI:10.1016/j.jtemb.2025.127655

Panpan Fang , Yingyuan Wang , Nan Chen , Kaijie Gao , Weihua Gong , Liu Yang , Qianqian Sun , Xuchen Wang , Tong Cai , Tiewei Li , Junmei Yang

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引用次数: 0

摘要

背景：贫血严重影响儿童的健康和生活质量，并可能受到体内各种微量金属水平的影响。目前关于微量金属与贫血的研究大多局限于单一金属，多种微量金属及其混合物与儿童贫血的关系尚不清楚。方法本研究利用2017-2020年国家健康与营养检查调查（NHANES）的横断面数据，包括2208名6-17岁的美国儿童，他们测试了五种微量金属：铅（Pb）、汞（Hg）、镉（Cd）、硒（Se）和锰（Mn）。该研究使用逻辑回归、分位数g计算和贝叶斯核机回归模型来检查这些金属如何单独和集体影响贫血，并确定重要的影响因素。并进行年龄分层分析，分析不同年龄组微量金属与贫血的关系。结果贫血患儿血Cd水平显著增高，硒、锰水平显著降低。在单变量金属模型中，硒水平的增加与贫血风险的降低有关。锰是学龄儿童贫血的主要保护因素，硒是青少年贫血的主要保护因素。qgComp和BKMR模型均显示混合微量金属暴露与贫血呈负相关。年龄特异性分析表明，微量金属的保护作用在青少年中并不明显。结论本研究发现，混合微量金属暴露与儿童贫血风险降低有关，硒在所有人群中都是一种保护因素。锰在学龄儿童中起保护作用，但在青少年中可能成为危险因素。

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Association of blood trace metals with anemia in children aged 6–17 years old

Background

Anemia significantly impacts children's health and quality of life, and may be influenced by the levels of various trace metals in the body. Current research on trace metals and anemia is mostly limited to single metals, and the association of multiple trace metals and their mixtures with anemia among children remains unclear.

Methods

This study utilized cross-sectional data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES), including 2208 children aged 6–17 years in the United States, who were tested for five trace metals: lead(Pb), mercury(Hg), cadmium(Cd), selenium(Se), and manganese(Mn). The study used logistic regression, quantile g-computation, and Bayesian kernel machine regression models to examine how these metals individually and collectively affect anemia and to identify significant influencing factors. Age-stratified analysis was also conducted to analyze the association of trace metals with anemia in different age groups.

Results

Children with anemia had significantly higher blood Cd levels and significantly lower Se and Mn levels. In the univariate metal model, increasing Se levels was associated with decreased anemia risk. Mn was the main protective factor for anemia in school-age children, while Se was the main protective factor in adolescents. Both qgComp and BKMR models showed a negative association between mixed trace metal exposure and anemia. The age-specific analysis showed that the protective effect of trace metals was not as apparent in adolescents.

Conclusion

This research discovered that mixed trace metal exposure was associated with a reduced risk of anemia in children, with Se acting as a protective factor across all populations. Mn played a protective role in school-age children but may become a risk factor in adolescents.

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.