钴酸铋（二碳内酯）（[o-COSAN]-）负载载铁蛋白：一种创新的高容量硼递送系统，用于BNCT应用于肿瘤细胞。

IF 5.8 3区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nanoscale Pub Date : 2025-04-14 DOI:10.1039/d5nr00362h

Diego Alberti, Julieta Nicole Pinas Marcos, Sahar Rakhshan, Nicoletta Protti, Saverio Altieri, Miquel Nuez, Francesc Teixidor, Clara Vinas, Simonetta Geninatti Crich

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引用次数: 0

摘要

这项研究描述了一种创新的载铁蛋白纳米杂化物，Apo:[o-COSAN]，作为一种高容量硼输送系统，在硼中子捕获治疗（BNCT）中有潜在的应用前景。这种纳米杂化物的特点是硼含量高，稳定性好，并且通过酸诱导的解离和重组过程，封装在载铁蛋白蛋白腔内，促进了钴胺（二碳内酯）（o-COSAN）的生物相互作用。Apo:[o-COSAN] - nanohybrid在MCF7乳腺癌和AB22间皮瘤细胞系中表现出增强的硼吸收，在生理条件下具有优异的稳定性和生物相容性。值得注意的是，用Apo:[o-COSAN]处理的AB22细胞在中子照射后表现出明显的细胞毒性作用，突出了该系统在BNCT中的潜力。这些发现强调了载铁蛋白作为靶向癌症治疗的多功能纳米载体的多功能性，将高硼有效载荷与选择性肿瘤细胞摄取相结合。

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Cobaltabis(dicarbollide) ([o-COSAN]-) loaded apoferritin: an innovative high-capacity boron delivery system to target tumour cells for BNCT applications.

This study describes an innovative apoferritin-based nanohybrid, Apo:[o-COSAN]⁻, as a high-capacity boron delivery system for potential application in Boron Neutron Capture Therapy (BNCT). The nanohybrid is characterized by a high boron content, stability, and the promotion of biological interactions of cobaltabis(dicarbollide) ([o-COSAN]⁻), encapsulated within the apoferritin protein cavity through an acid-induced dissociation and reassembly process. The Apo:[o-COSAN]⁻ nanohybrid demonstrated enhanced boron uptake in MCF7 breast cancer and AB22 mesothelioma cell lines, with superior stability and biocompatibility under physiological conditions. Notably, AB22 cells treated with Apo:[o-COSAN]⁻ showed significant cytotoxic effects following neutron irradiation, highlighting the potential of this system in BNCT. These findings underscore the versatility of apoferritin as a multifunctional nanocarrier for targeted cancer therapy, combining high boron payloads with selective tumour cell uptake.

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来源期刊

Nanoscale CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

12.10

自引率

3.00%

发文量

1628

审稿时长

1.6 months

期刊介绍： Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.