R. G. Bribiescas, A. Sancilio, D. Amir, T. J. Cepon-Robins, T. Gildner, M. A. Liebert, F. Madimenos, S. S. Urlacher, J. Snodgrass, L. Sugiyama
{"title":"睾酮，8-氧-2 ' -脱氧鸟苷（8-OHdG）和Cu/Zn超氧化物歧化酶（SOD）在亚马逊厄瓜多尔成年Shuar男性：生殖努力和氧化应激之间权衡的证据测试","authors":"R. G. Bribiescas, A. Sancilio, D. Amir, T. J. Cepon-Robins, T. Gildner, M. A. Liebert, F. Madimenos, S. S. Urlacher, J. Snodgrass, L. Sugiyama","doi":"10.1002/ajhb.70042","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>Reproductive effort incurs the cost of biological aging and morbidity by compromising somatic maintenance when key resources are limited. Oxidative stress is positively correlated with reproductive effort in adult human females and non-human male animal models, but human males are understudied. We hypothesized that due to its anabolic and metabolic promotion of reproductive effort in human males, testosterone would be positively associated with biomarkers of oxidative stress.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Urinary testosterone in adult Shuar males of Amazonia Ecuador, a foraging/horticultural population, was measured with urinary 8-hydroxy-2′ -deoxyguanosine (8-OHdG), a biomarker of oxidative stress, and Cu/Zn superoxide dismutase (Cu/Zn SOD), a protective antioxidant against oxidative stress. Age and anthropometric measures were included in multivariate models.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>No significant correlation was observed between testosterone and 8-OHdG, <i>r</i><sup>2</sup> = 0.01, <i>p</i> = 0.61, <i>n</i> = 29, or Cu/Zn SOD, <i>r</i><sup>2</sup> = 0.0005, <i>p</i> = 0.93, <i>n</i> = 17. Multiple linear regression models including testosterone, Cu/Zn SOD, anthropometrics, and age, with 8-OHdG as the dependent variable, were modestly supportive of an association. The most parsimonious 8-OHdG model included age, Cu/Zn SOD, and testosterone (<i>R</i><sup>2 adjusted</sup> = 0.38, <i>p</i> = 0.04, AICc = 141.95). All multivariate models for Cu/Zn SOD were not significant (<i>p</i> > 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Oxidative stress may not be a cost of reproductive effort in this population of adult males; perhaps due to consistently low testosterone levels in non-industrialized populations, differences in the metabolic cost of reproductive effort between males and females (i.e., aerobic metabolism), and/or study limitations based on cross-sectional measures of oxidative stress and testosterone.</p>\n </section>\n </div>","PeriodicalId":50809,"journal":{"name":"American Journal of Human Biology","volume":"37 4","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Testosterone, 8-Oxo-2′-Deoxyguanosine (8-OHdG) and Cu/Zn Superoxide Dismutase (SOD) in Adult Shuar Males of Amazonian Ecuador: A Test for Evidence of Trade-Offs Between Reproductive Effort and Oxidative Stress\",\"authors\":\"R. G. Bribiescas, A. Sancilio, D. Amir, T. J. Cepon-Robins, T. Gildner, M. A. Liebert, F. Madimenos, S. S. Urlacher, J. Snodgrass, L. Sugiyama\",\"doi\":\"10.1002/ajhb.70042\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>Reproductive effort incurs the cost of biological aging and morbidity by compromising somatic maintenance when key resources are limited. Oxidative stress is positively correlated with reproductive effort in adult human females and non-human male animal models, but human males are understudied. We hypothesized that due to its anabolic and metabolic promotion of reproductive effort in human males, testosterone would be positively associated with biomarkers of oxidative stress.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Urinary testosterone in adult Shuar males of Amazonia Ecuador, a foraging/horticultural population, was measured with urinary 8-hydroxy-2′ -deoxyguanosine (8-OHdG), a biomarker of oxidative stress, and Cu/Zn superoxide dismutase (Cu/Zn SOD), a protective antioxidant against oxidative stress. Age and anthropometric measures were included in multivariate models.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>No significant correlation was observed between testosterone and 8-OHdG, <i>r</i><sup>2</sup> = 0.01, <i>p</i> = 0.61, <i>n</i> = 29, or Cu/Zn SOD, <i>r</i><sup>2</sup> = 0.0005, <i>p</i> = 0.93, <i>n</i> = 17. Multiple linear regression models including testosterone, Cu/Zn SOD, anthropometrics, and age, with 8-OHdG as the dependent variable, were modestly supportive of an association. The most parsimonious 8-OHdG model included age, Cu/Zn SOD, and testosterone (<i>R</i><sup>2 adjusted</sup> = 0.38, <i>p</i> = 0.04, AICc = 141.95). All multivariate models for Cu/Zn SOD were not significant (<i>p</i> > 0.05).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Oxidative stress may not be a cost of reproductive effort in this population of adult males; perhaps due to consistently low testosterone levels in non-industrialized populations, differences in the metabolic cost of reproductive effort between males and females (i.e., aerobic metabolism), and/or study limitations based on cross-sectional measures of oxidative stress and testosterone.</p>\\n </section>\\n </div>\",\"PeriodicalId\":50809,\"journal\":{\"name\":\"American Journal of Human Biology\",\"volume\":\"37 4\",\"pages\":\"\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Human Biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ajhb.70042\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ANTHROPOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Human Biology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ajhb.70042","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ANTHROPOLOGY","Score":null,"Total":0}
Testosterone, 8-Oxo-2′-Deoxyguanosine (8-OHdG) and Cu/Zn Superoxide Dismutase (SOD) in Adult Shuar Males of Amazonian Ecuador: A Test for Evidence of Trade-Offs Between Reproductive Effort and Oxidative Stress
Objectives
Reproductive effort incurs the cost of biological aging and morbidity by compromising somatic maintenance when key resources are limited. Oxidative stress is positively correlated with reproductive effort in adult human females and non-human male animal models, but human males are understudied. We hypothesized that due to its anabolic and metabolic promotion of reproductive effort in human males, testosterone would be positively associated with biomarkers of oxidative stress.
Methods
Urinary testosterone in adult Shuar males of Amazonia Ecuador, a foraging/horticultural population, was measured with urinary 8-hydroxy-2′ -deoxyguanosine (8-OHdG), a biomarker of oxidative stress, and Cu/Zn superoxide dismutase (Cu/Zn SOD), a protective antioxidant against oxidative stress. Age and anthropometric measures were included in multivariate models.
Results
No significant correlation was observed between testosterone and 8-OHdG, r2 = 0.01, p = 0.61, n = 29, or Cu/Zn SOD, r2 = 0.0005, p = 0.93, n = 17. Multiple linear regression models including testosterone, Cu/Zn SOD, anthropometrics, and age, with 8-OHdG as the dependent variable, were modestly supportive of an association. The most parsimonious 8-OHdG model included age, Cu/Zn SOD, and testosterone (R2 adjusted = 0.38, p = 0.04, AICc = 141.95). All multivariate models for Cu/Zn SOD were not significant (p > 0.05).
Conclusions
Oxidative stress may not be a cost of reproductive effort in this population of adult males; perhaps due to consistently low testosterone levels in non-industrialized populations, differences in the metabolic cost of reproductive effort between males and females (i.e., aerobic metabolism), and/or study limitations based on cross-sectional measures of oxidative stress and testosterone.
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The American Journal of Human Biology is the Official Journal of the Human Biology Association.
The American Journal of Human Biology is a bimonthly, peer-reviewed, internationally circulated journal that publishes reports of original research, theoretical articles and timely reviews, and brief communications in the interdisciplinary field of human biology. As the official journal of the Human Biology Association, the Journal also publishes abstracts of research presented at its annual scientific meeting and book reviews relevant to the field.
The Journal seeks scholarly manuscripts that address all aspects of human biology, health, and disease, particularly those that stress comparative, developmental, ecological, or evolutionary perspectives. The transdisciplinary areas covered in the Journal include, but are not limited to, epidemiology, genetic variation, population biology and demography, physiology, anatomy, nutrition, growth and aging, physical performance, physical activity and fitness, ecology, and evolution, along with their interactions. The Journal publishes basic, applied, and methodologically oriented research from all areas, including measurement, analytical techniques and strategies, and computer applications in human biology.
Like many other biologically oriented disciplines, the field of human biology has undergone considerable growth and diversification in recent years, and the expansion of the aims and scope of the Journal is a reflection of this growth and membership diversification.
The Journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscripts of unusual interest.
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