Design, Synthesis, and Anticandidiasis Assessment of New Fluorine Containing Pyrimidines

Candida albicans, a type of fungi, is quite adaptable and can survive in various parts of the body including bloodstream, skin, mucosal surfaces, and different organs. This pathogen can cause debilitating mucocutaneous disease and life-threatening systemic infections in humans. In this study, we investigated how effective newly synthesized pyrimidine derivatives are as antifungal agents. Pyrimidines are special compounds made of six-membered rings containing two nitrogen atoms. We have synthesized different pyrimidine molecules by substituting hydrogen by mono- and di-fluorophenyl. Further all synthesized molecules were tested against the C. albicans. We have shown that pyrimidine derivatives (80, 40, and 20 µg/mL) exhibit inhibitory effect at all growth stages: adhesion, development, and maturation of biofilm formation. Overall, this study presents the design, synthesis, and anticandidal evaluation of a novel class of pyrimidine derivatives. Specifically, we observe that the fluorine-substituted pyrimidine derivatives exhibit inhibition against C. albicans. These findings contribute to the development of more potent pyrimidine-based antifungal derivatives.