马齿苋中两种吡啶类生物碱及其抗炎和抗氧化活性

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-03-25 DOI:10.1007/s10600-025-04646-x

Xiaoqian Zhang, Shuangshuo Liu, Wenjuan Wei, Jing Liu, Pengyan Liu, Ying Yang, Xixiang Ying

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引用次数: 0

摘要

从马齿苋中获得了两种吡啶生物碱--5-乙氧基吡啶-2-醇，分别命名为马齿苋吡啶醇（1）和5-羟基烟酸甲酯（2），其中化合物1为新化合物，化合物2为首次从马齿苋中分离得到。化合物 1 的结构是通过 UHPLC-ESI-Q-TOF/MS, 1D, 2D NMR 确定的。化合物 1-2 具有抗氧化活性，IC50 值分别为 42.625 ± 0.37 和 37.423 ± 0.43 μM。此外，还研究了化合物 1-2 对脂多糖刺激的巨噬细胞的抗炎作用。

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Two Pyridine Alkaloids from Portulaca oleracea and their Anti-Inflammatory and Antioxidant Activities

Two pyridine alkaloids, 5-ethoxypyridin-2-ol, named olerapyridineol (1) and methyl 5-hydroxynicotinate (2), were obtained from the Portulaca oleracea L., from which compound 1 was the new compound and compound 2 was isolated from P. oleracea for the first time. The structure of compound 1 was identified by UHPLC-ESI-Q-TOF/MS, 1D, 2D NMR. Compounds 1–2 presented antioxidant activities with IC₅₀ values of 42.625 ± 0.37, 37.423 ± 0.43 μM. In addition, the anti-inflammatory effects on lipopolysaccharide-stimulated macrophages of compounds 1–2 were also investigated.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.