鲁丙酮酸衍生物的设计合成及其细胞毒活性评价

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-03-29 DOI:10.1007/s10600-025-04632-3

R. Y. Zhu, Kh. Bozorov, H. A. Aisa, J. Y. Zhao

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引用次数: 0

摘要

设计并合成了20种新型鲁丙酮酸酰胺。对四种人类癌细胞系（HeLa、HT-29、A549和HepG2）进行了细胞毒活性评估。酰胺衍生物2e对A549细胞（IC50 = 4.73 μM）和HT-29细胞（IC50 = 7.55 μM）具有细胞毒活性；1a，抗HeLa细胞（IC50 = 13.95 μM）；1d，对HepG2细胞（IC50 = 11.12 μM）。

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Design and Synthesis of Rupestonic Acid Derivatives and Assessment of Their Cytotoxic Activity

Twenty novel rupestonic acid amides were designed and synthesized. Their cytotoxic activity was assessed against four human cancer cell lines (HeLa, HT-29, A549, and HepG2). Amide derivative 2e exhibited cytotoxic activity against A549 (IC₅₀ = 4.73 μM) and HT-29 cells (IC₅₀ = 7.55 μM); 1a, against HeLa cells (IC₅₀ = 13.95 μM); 1d, against HepG2 cells (IC₅₀ = 11.12 μM).

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.