从Diorygma sp.培养的地衣真菌中分离出一种新的瓜蓝烷倍半萜。

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-03-27 DOI:10.1007/s10600-025-04633-2

Nguyen-Hong-Nhi Phan, Thuc-Huy Duong, Huy Truong Nguyen, Thi-Hoai-Thu Nguyen, Ngoc-Hong Nguyen, Thi-Phi-Giao Vo, Thi-Minh-Dinh Tran, Jirapast Sichaem

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引用次数: 0

摘要

对越南硬壳地衣Diorygma sp.培养的真菌进行了化学研究，分离并鉴定了一种新的愈创烷倍半萜，diorygmone F(1)，以及三种已知化合物，prinosone， β-谷甾醇和4-羟基苯甲酸甲酯。通过广泛的光谱方法，包括NMR， HR-ESI-MS和ECD，实现了结构解析。化合物1对α-葡萄糖苷酶具有一定的抑制活性，IC50值为131±1.4 μM，对HepG2癌细胞无细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A New Guaiane Sesquiterpene from the Cultured Lichen Mycobiont of Diorygma sp.

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A New Guaiane Sesquiterpene from the Cultured Lichen Mycobiont of Diorygma sp.

The cultured mycobiont of the Vietnamese crustose lichen Diorygma sp. was subjected to chemical investigation, which led to the isolation and characterization of a new guaiane sesquiterpene, diorygmone F (1), along with three known compounds, pruinosone, β-sitosterol, and methyl 4-hydroxybenzoate. Structural elucidation was achieved through extensive spectroscopic methods, including NMR, HR-ESI-MS, and ECD. Compound 1 displayed modest inhibitory activity against α-glucosidase, with an IC₅₀ value of 131 ± 1.4 μM, and showed no cytotoxicity against the HepG2 cancer cell line.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.