5α-孕烯醇酮向某些腙的转化：合成及其生物活性

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI:10.1007/s10600-025-04634-1

N. Sh. Nadaraia, N. N. Barbakadze, T. B. Kvaratskhelia, M. L. Kakhabrishvili, J. Legault, K. G. Mulkidzhanyan, V. D. Mshvildadze

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引用次数: 0

摘要

在从孕-16-烯-3β-醇-20-酮中寻找生物活性类固醇的过程中，合成了三个系列的含 N 的 5α 类固醇。利用 1H NMR、13C NMR 和质谱证明了合成化合物的结构。对 14 种合成类固醇的体外细胞毒性、抗炎和抗氧化活性进行了研究，发现 4 种化合物具有明显的抗炎活性，1 种化合物对结直肠腺癌细胞具有细胞毒性活性。

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Transformation of 5α-Pregnenolone Into Some Hydrazones: Synthesis and Biological Activity

Three series of N-containing 5α-steroids were synthesized during a search for biologically active steroids from pregn-16-en-3β-ol-20-one. The structures of the synthesized compounds were proved using ¹H NMR, ¹³C NMR, and mass spectra. Studies of the in vitro cytotoxic, anti-inflammatory, and antioxidant activity of 14 synthesized steroids identified four compounds with pronounced anti-inflammatory activity and one with cytotoxic activity against colorectal adenocarcinoma cells.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.