二氢白桦素和二氢鲁皮醇肟A环的贝克曼断裂

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI:10.1007/s10600-025-04635-0

G. F. Krainova, V. V. Grishko

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引用次数: 0

摘要

A-Secolupane nitriles 环 A 上有一个醛基或甲基酮片段，并有一个裂开的 C2-C3 或 C3-C4 键，是通过二氢甜菊素和二氢羽扇豆醇的肟衍生物的贝克曼反应合成的。利用在线 PASS 服务进行的生物特性预测分析表明，合成的三萜衍生物有望成为抗肿瘤药物。

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Beckmann Fragmentation of Ring A of Dihydrobetulin and Dihydrolupeol Oximes

A-Secolupane nitriles with an aldehyde group or methylketone fragment on ring A and a cleaved C2–C3 or C3–C4 bond were synthesized via Beckmann reactions of oxime derivatives of dihydrobetulin and dihydrolupeol. A predictive analysis of the biological properties using the online PASS service indicated the synthesized triterpene derivatives were promising as antitumor agents.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.