泽兰苯丙类新衍生物及抗炎成分研究

IF 0.8 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-03-26 DOI:10.1007/s10600-025-04626-1

Ching-Ju Hung, Zih-Rong Chen, Chien-Liang Lin, Tsung-Hsien Chang, Ming-Jen Cheng, Jih-Jung Chen

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引用次数: 0

摘要

从紫茎泽兰根中分离到一个新的苯丙类衍生物1-（2-羟基-4-（羟甲基）苯基）丙烷-1,2-二酮(1)，并分离到7个已知化合物：10-乙酰氧基-8-羟基-9- o -angeloylthymol(2)、9-乙酰氧基-8,10-环氧百里酚3- o -tiglate(3)、9-angeloyl -8,10-脱氢百里酚(4)、9- o -angeloyl-8,10-脱氢百里酚(5)、芦丁(6)、紫托林(7)和香豆素(8)。其中化合物1、2、4和6对lps诱导的NO生成具有较强的抑制作用，IC50值分别为27.69±2.73、25.02±3.07、19.18±1.64和10.05±0.78 mM。

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New Phenylpropanoid Derivative and Anti-Inflammatory Constituents from Eupatorium amabile

A new phenylpropanoid derivative, 1-(2-hydroxy-4-(hydroxymethyl)phenyl)propane-1,2-dione (1), has been isolated from the roots of Eupatorium amabile, together with seven known compounds, 10-acetoxy-8-hydroxy-9-O-angeloylthymol (2), 9-acetoxy-8,10-epoxythymol 3-O-tiglate (3), 9-angeloyloxythymol (4), 9-O-angeloyl-8,10-dehydrothymol (5), rutin (6), eupatorin (7), and coumarin (8). The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolated compounds, compounds 1, 2, 4, and 6 showed potent inhibition with IC₅₀ values of 27.69 ± 2.73, 25.02 ± 3.07, 19.18 ± 1.64, and 10.05 ± 0.78 mM, respectively, against LPS-induced NO generation.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.