n -乙烯酰亚胺与烷基、硅基和酰基自由基的模块化还原自由基-极性交叉酰基迁移反应

IF 4.6 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

RSC Advances Pub Date : 2025-04-15 DOI:10.1039/D5RA01542A

Yutao Jing, Li Zhang, Li Qiu and Yewen Fang

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引用次数: 0

摘要

在此，我们成功开发了基于 SET 还原法的新型 N → C酰基迁移方案，用于制备功能化 α-氨基酮。除烷基和硅基自由基外，来自二氢喹唑啉酮或酰基肟醋酸酯的酰基也能与烯酰胺发生反应，生成各种 1,4-二酮。这些光催化自由基加成/酰基迁移级联反应具有广泛的底物范围、良好的官能团兼容性和温和的反应条件。

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Modular reductive radical-polar crossover-based acyl migration reactions of N-vinylimides with alkyl, silyl, and acyl radicals†

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Modular reductive radical-polar crossover-based acyl migration reactions of N-vinylimides with alkyl, silyl, and acyl radicals†

Herein, novel SET reduction-based N → C acyl migration protocols for the preparation of functionalized α-amino ketones were successfully developed. In addition to alkyl and silyl radicals, acyl radicals derived from dihydroquinazolinones or acyl oxime acetates could react with enamides to give various 1,4-diketones. These photocatalytic radical addition/acyl migration cascade reactions feature broad substrate scope, good functional group compatibility, and mild reaction conditions.

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来源期刊

RSC Advances chemical sciences-

CiteScore

7.50

自引率

2.60%

发文量

3116

审稿时长

1.6 months

期刊介绍： An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.