评估流感疫苗对预防中国老年高血压患者中风住院和死亡的影响：回顾性队列研究

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-04-15 DOI:10.1016/j.vaccine.2025.127004

Feng Tong , Tianshu Zhou , Ling Tang , Xiaoqing Wu , Tianchi Yang , Lixia Ye

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Evaluating the impact of influenza vaccine on preventing stroke hospitalization and death in Chinese elderly hypertensive patients: A retrospective cohort study

Background

The effect of influenza vaccination on stroke remains controversial, particularly given the paucity of studies conducted in mainland China.

Methods

Using a comprehensive database obtained from the Regional Health Information Platform, we conducted a 7-month retrospective cohort analysis of 457,887 elderly individuals residing in an eastern Chinese city. Using multivariate competing risks regression analysis, we derived subdistribution hazard ratios (sHRs) along with the corresponding 95 % confidence intervals (CIs).

Results

There was no significant difference in the proportion of hospitalizations for stroke between those who received the influenza vaccine and those who did not (7.50 per 1000 vs. 8.12 per 1000; adjusted sHR: 0.96, 95 % CI: 0.90–1.02). However, a pronounced reduction in stroke-related mortality was observed among vaccinated individuals, with a rate of 0.18 ‰ compared with 0.54 ‰ among the unvaccinated (adjusted sHR: 0.47, 95 % CI: 0.33–0.69).

Conclusion

This study highlights the substantial role of influenza vaccination in reducing the risk of stroke-related mortality in elderly hypertensive patients. Therefore, efforts to increase influenza vaccination rates in this population are strongly encouraged.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.