导电MeCbl/PEDOT:PSS/HA水凝胶与电刺激增强周围神经再生

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2025-04-10 DOI:10.1016/j.mtbio.2025.101755

Kai Liu , Jiangbo Shao , Beibei Han , Jianfeng Liu , Shuai Yan , Bin Liu , Yao Liu

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引用次数: 0

摘要

由于周围神经系统（PNS）的再生能力有限，周围神经再生（PNR）是医学领域的一个重大挑战。目前的研究重点是开发先进的医用高分子材料，以增强神经的恢复。尽管取得了重大进展，但仍有几个关键问题尚未解决，包括生物相容性、稳定性、机械强度、控制降解率和治疗剂的持续释放。本研究探讨了透明质酸水凝胶，掺杂甲氧巴胺（MeCbl）和导电聚（3,4-乙烯二氧噻吩）：聚苯乙烯磺酸盐（PEDOT:PSS），结合外源性电刺激（ES）对大鼠PNR的应用。该策略利用MeCbl水凝胶创造再生微环境，为神经细胞提供营养支持，而PEDOT:PSS则有助于增强电信号传导。ES已被证明可以促进PNR和功能恢复，因此显示出相当大的潜力。本研究旨在全面分析这种联合治疗方法的协同效应和潜在价值，为有效的PNR提供新的见解和途径。

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Conductive MeCbl/PEDOT:PSS/HA hydrogels with electrical stimulation for enhanced peripheral nerve regeneration

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Conductive MeCbl/PEDOT:PSS/HA hydrogels with electrical stimulation for enhanced peripheral nerve regeneration

Peripheral nerve regeneration (PNR) represents a substantial challenge in the medical field, primarily due to the limited regenerative capacity of the peripheral nerve system (PNS). Current research efforts are focused on developing advanced medical polymer materials to enhance nerve recovery. Despite significant progress, several critical issues remain unresolved, including biocompatibility, stability, mechanical strength, controlled degradation rates, and sustained release of therapeutic agents. This study examines the utilization of hyaluronic acid hydrogels, doped with mecobalamin (MeCbl) and conductive poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), in combination with exogenous electrical stimulation (ES) for PNR of rats. The strategy utilizes the MeCbl hydrogel to create a regenerative microenvironment and provide nutritional support for nerve cells, while PEDOT:PSS facilitates enhanced electrical signal conduction. ES has been shown to promote PNR and functional recovery, thereby demonstrating considerable potential. This study aims to comprehensively analyze the synergistic effects and potential value of this combined therapeutic approach, providing novel insights and pathways for the effective PNR.

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).