毛细管电迁移技术手性分析

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-04-08 DOI:10.1016/j.trac.2025.118256

Samuel Bernardo-Bermejo , Sandra Adámez-Rodríguez , María Castro-Puyana , María Luisa Marina

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引用次数: 0

摘要

手性在不同的科学学科中表现出的巨大影响，可以通过开发大量的分析方法来实现手性化合物对映体的分离和测定。毛细管电迁移（CE）技术已被证明是非常强大的手性分离工具，因为其固有的特性，如高分离效率和分辨率，以及通过在分离介质中添加手性选择剂来区分对映体的可能性，如在电动色谱中。这篇综述描述了从2020年到现在CE技术对手性分析的最相关贡献。介绍了过去几年报告的主要进展以及手性CE技术在药物/化妆品配方、生物、食品或农化/环境样品分析中的最具代表性的应用。已开发的方法的特点在表格中分组，并与本主题预期的未来趋势一起进行批判性讨论。

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Chiral analysis by capillary electromigration techniques

The big impact that chirality presents in different scientific disciplines is illustrated by the high number of analytical methodologies developed to achieve the separation and determination of the enantiomers of chiral compounds. Capillary Electromigration (CE) techniques have demonstrated to be very powerful tools for chiral separations due to their inherent characteristics such as high separation efficiency and resolution, and the possibility of discriminating enantiomers by adding a chiral selector to the separation medium as in Electrokinetic Chromatography. This review describes the most relevant contributions of CE techniques to chiral analysis from 2020 to the present. The main advances reported in the last years are presented together with the most representative applications of chiral CE techniques to the analysis of pharmaceutical/cosmetic formulations, and biological, food, or agrochemical/environmental samples. The characteristics of the developed methodologies are grouped in tables and critically discussed together with the future trends expected in this topic.

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.