纳米颗粒药物对幽门螺杆菌感染和胃癌的影响

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2025-04-11 DOI:10.1016/j.genrep.2025.102223

Zahra Ebrahimi , Hana Hamid , Parisa Salari , Meysam Beyrami , Maryam Moradi Binabaj

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引用次数: 0

摘要

胃肠道疾病影响了全球人口的很大一部分，并对医疗领域构成了重大挑战。耐药、不良反应和药物疗效低是治疗这些疾病的关键问题。幽门螺杆菌（Helicobacter pylori， H. pylori）是一种主要的致病菌，会导致胃肠道疾病。纳米药物的开发代表了现代治疗策略的发展方向，具有重要的作用。在改善药代动力学和减少与传统治疗相关的并发症。本文综述了氧化锌（ZnONPs）、金（AuNPs）、壳聚糖（CSNPs）和银（AgNPs）这四种广泛应用的NP抗幽门螺杆菌感染的作用，并探讨了它们在制药系统设计和优化中的应用。这些NPs表现出广泛的抗菌机制，从破坏细菌细胞完整性到产生活性氧（ROS）。它们在胃癌治疗中也显示出希望，特别是与其他抗菌剂联合使用时，可以增强抗h。幽门螺杆菌和抗癌活性近年来，NPs作为药物载体应用于给药系统。NPs的这种创新应用显示了优化药物疗效和靶向细胞递送的潜力，特别是在癌症治疗中。

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The effects of nanoparticle based drugs on Helicobacter pylori infection and gastric cancer

Gastrointestinal diseases affect a significant portion of the global population and pose major challenges in the medical field. Drug resistance, adverse effects, and low drug's efficacy are among the critical issues in treating these diseases. Helicobacter pylori (H. pylori) a major pathogenic bacterium, contributes to gastrointestinal diseases. Developing nano agents represents a modern perspective in therapeutic strategies, with a noteworthy role. In improving pharmacokinetics and reducing complications associated with conventional treatments. This review investigates the effects of four widely used NPs (zinc oxide (ZnONPs), gold (AuNPs), chitosan (CSNPs), and silver (AgNPs)) against H. pylori infection and explores their applications NP in pharmaceutical system design and optimization. These NPs exhibit a wide range of antimicrobial mechanisms, from disrupting bacterial cell integrity to generating reactive oxygen species (ROS). They also show promise in gastric cancer treatment, particularly when combined with other antibacterial agents, enhancing their anti-H. pylori and anticancer activities. Recently, NPs have been applied as drug carriers in drug delivery systems. This innovative use of NPs shows potential for optimizing drug efficacy and targeted cell delivery, particularly in cancer treatment.

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.