{"title":"刚地弓形虫翻译后修饰的功能及其作为药物靶点的潜力","authors":"Chenghuan Li, Xing-Quan Zhu, Qijun Chen","doi":"10.1155/tbed/8359440","DOIUrl":null,"url":null,"abstract":"<div>\n <p><i>Toxoplasma gondii</i> is an obligate intracellular apicomplexan parasite. Currently, the effective drugs for the treatment of toxoplasmosis are mainly pyrimethamine and sulfonamide, but these drugs have high toxicity and side effects, so the search for new and effective drug targets is urgent. Posttranslational modifications (PTMs) are certain chemical groups that are covalently coupled to specific amino acids within a protein. Studies have shown that <i>T. gondii</i> expresses a variety of proteins that require PTMs to regulate the parasite’s response to extracellular stimuli and life cycle transitions at different developmental stages. In this review, we summarize and analyze the 14 PTMs that have been found in <i>T. gondii</i> proteins to date and their roles in <i>T. gondii</i> growth and development. In addition, we discuss the potential crosstalk between <i>T. gondii</i> PTMs at different stages and summarize the results of studies on inhibitors that target PTM regulatory factors. The aim is to further analyze the functions of PTMs in the development and pathogenesis of <i>T. gondii</i> and to lay the foundation for the search for new anti-<i>T. gondii</i> drug targets.</p>\n </div>","PeriodicalId":234,"journal":{"name":"Transboundary and Emerging Diseases","volume":"2025 1","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbed/8359440","citationCount":"0","resultStr":"{\"title\":\"Functions of Posttranslational Modifications in Toxoplasma gondii and Their Potential as Drug Targets\",\"authors\":\"Chenghuan Li, Xing-Quan Zhu, Qijun Chen\",\"doi\":\"10.1155/tbed/8359440\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n <p><i>Toxoplasma gondii</i> is an obligate intracellular apicomplexan parasite. Currently, the effective drugs for the treatment of toxoplasmosis are mainly pyrimethamine and sulfonamide, but these drugs have high toxicity and side effects, so the search for new and effective drug targets is urgent. Posttranslational modifications (PTMs) are certain chemical groups that are covalently coupled to specific amino acids within a protein. Studies have shown that <i>T. gondii</i> expresses a variety of proteins that require PTMs to regulate the parasite’s response to extracellular stimuli and life cycle transitions at different developmental stages. In this review, we summarize and analyze the 14 PTMs that have been found in <i>T. gondii</i> proteins to date and their roles in <i>T. gondii</i> growth and development. In addition, we discuss the potential crosstalk between <i>T. gondii</i> PTMs at different stages and summarize the results of studies on inhibitors that target PTM regulatory factors. The aim is to further analyze the functions of PTMs in the development and pathogenesis of <i>T. gondii</i> and to lay the foundation for the search for new anti-<i>T. gondii</i> drug targets.</p>\\n </div>\",\"PeriodicalId\":234,\"journal\":{\"name\":\"Transboundary and Emerging Diseases\",\"volume\":\"2025 1\",\"pages\":\"\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-04-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbed/8359440\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transboundary and Emerging Diseases\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1155/tbed/8359440\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transboundary and Emerging Diseases","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/tbed/8359440","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Functions of Posttranslational Modifications in Toxoplasma gondii and Their Potential as Drug Targets
Toxoplasma gondii is an obligate intracellular apicomplexan parasite. Currently, the effective drugs for the treatment of toxoplasmosis are mainly pyrimethamine and sulfonamide, but these drugs have high toxicity and side effects, so the search for new and effective drug targets is urgent. Posttranslational modifications (PTMs) are certain chemical groups that are covalently coupled to specific amino acids within a protein. Studies have shown that T. gondii expresses a variety of proteins that require PTMs to regulate the parasite’s response to extracellular stimuli and life cycle transitions at different developmental stages. In this review, we summarize and analyze the 14 PTMs that have been found in T. gondii proteins to date and their roles in T. gondii growth and development. In addition, we discuss the potential crosstalk between T. gondii PTMs at different stages and summarize the results of studies on inhibitors that target PTM regulatory factors. The aim is to further analyze the functions of PTMs in the development and pathogenesis of T. gondii and to lay the foundation for the search for new anti-T. gondii drug targets.
期刊介绍：
Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions):
Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread.
Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope.
Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies.
Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies).
Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.
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