Longbing Ren, Fan Hu, Sebastian Walsh, Xurui Jin, Yang Hu, Shaojie Li, Yuling Jiang, Mingzhi Yu, Yifei Wu, Grace Yuange Zang, Keyang Liu, Huashuai Chen, Jing Sun, Yan Zhang, Kokoro Shirai, Yi Zeng, Quincy M. Samus, Gill Livingston, Yao Yao
{"title":"健康生活方式因素超过APOE遗传风险对延长中国老年人认知健康预期寿命的影响：来自全国队列研究的证据","authors":"Longbing Ren, Fan Hu, Sebastian Walsh, Xurui Jin, Yang Hu, Shaojie Li, Yuling Jiang, Mingzhi Yu, Yifei Wu, Grace Yuange Zang, Keyang Liu, Huashuai Chen, Jing Sun, Yan Zhang, Kokoro Shirai, Yi Zeng, Quincy M. Samus, Gill Livingston, Yao Yao","doi":"10.1002/alz.70090","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Understanding the interplay between genetic factors and lifestyle choices in cognitive health is crucial for enhancing late-life quality. This study examines the effects of Apolipoprotein E (APOE) genotypes and healthy lifestyles on life expectancy with and without cognitive impairment (CI) in Chinese older adults.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>Data from 6488 participants aged at least 65 in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were analyzed using continuous-time three-state Markov models. Cognitive function was assessed with the Mini-Mental State Examination (MMSE).</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>APOE ε4 allele carriers had a higher risk of transitioning from cognitively healthy (CH) to impaired, while ε2 carriers had a reduced risk of transitioning from healthy to death. Participants with 4 or 5 healthy lifestyle factors experienced significant protective effects, extending the cognitively healthy life expectancy.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>These findings underscore the importance of promoting healthy lifestyles to delay cognitive decline, regardless of genetic predispositions, particularly in the Asian context.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Compared with ε3 homozygotes, APOE ε4 carriers in China have a higher risk of transitioning from CH to CI, and APOE ε2 carriers with CH have a lower risk of transitioning to death.</li>\n \n <li>Healthy lifestyles can extend life expectancy, primarily extending CH life expectancy.</li>\n \n <li>Healthy lifestyles reduce the risk of CI and delay its onset in later life, regardless of APOE genetic risk.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 4","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70090","citationCount":"0","resultStr":"{\"title\":\"Healthy lifestyle factors outweigh influence of APOE genetic risk on extending cognitively healthy life expectancy among Chinese older adults: evidence from a nationwide cohort study\",\"authors\":\"Longbing Ren, Fan Hu, Sebastian Walsh, Xurui Jin, Yang Hu, Shaojie Li, Yuling Jiang, Mingzhi Yu, Yifei Wu, Grace Yuange Zang, Keyang Liu, Huashuai Chen, Jing Sun, Yan Zhang, Kokoro Shirai, Yi Zeng, Quincy M. Samus, Gill Livingston, Yao Yao\",\"doi\":\"10.1002/alz.70090\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>Understanding the interplay between genetic factors and lifestyle choices in cognitive health is crucial for enhancing late-life quality. This study examines the effects of Apolipoprotein E (APOE) genotypes and healthy lifestyles on life expectancy with and without cognitive impairment (CI) in Chinese older adults.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>Data from 6488 participants aged at least 65 in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were analyzed using continuous-time three-state Markov models. Cognitive function was assessed with the Mini-Mental State Examination (MMSE).</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>APOE ε4 allele carriers had a higher risk of transitioning from cognitively healthy (CH) to impaired, while ε2 carriers had a reduced risk of transitioning from healthy to death. Participants with 4 or 5 healthy lifestyle factors experienced significant protective effects, extending the cognitively healthy life expectancy.</p>\\n </section>\\n \\n <section>\\n \\n <h3> DISCUSSION</h3>\\n \\n <p>These findings underscore the importance of promoting healthy lifestyles to delay cognitive decline, regardless of genetic predispositions, particularly in the Asian context.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>Compared with ε3 homozygotes, APOE ε4 carriers in China have a higher risk of transitioning from CH to CI, and APOE ε2 carriers with CH have a lower risk of transitioning to death.</li>\\n \\n <li>Healthy lifestyles can extend life expectancy, primarily extending CH life expectancy.</li>\\n \\n <li>Healthy lifestyles reduce the risk of CI and delay its onset in later life, regardless of APOE genetic risk.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"21 4\",\"pages\":\"\"},\"PeriodicalIF\":13.0000,\"publicationDate\":\"2025-04-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70090\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/alz.70090\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/alz.70090","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Healthy lifestyle factors outweigh influence of APOE genetic risk on extending cognitively healthy life expectancy among Chinese older adults: evidence from a nationwide cohort study
INTRODUCTION
Understanding the interplay between genetic factors and lifestyle choices in cognitive health is crucial for enhancing late-life quality. This study examines the effects of Apolipoprotein E (APOE) genotypes and healthy lifestyles on life expectancy with and without cognitive impairment (CI) in Chinese older adults.
METHODS
Data from 6488 participants aged at least 65 in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were analyzed using continuous-time three-state Markov models. Cognitive function was assessed with the Mini-Mental State Examination (MMSE).
RESULTS
APOE ε4 allele carriers had a higher risk of transitioning from cognitively healthy (CH) to impaired, while ε2 carriers had a reduced risk of transitioning from healthy to death. Participants with 4 or 5 healthy lifestyle factors experienced significant protective effects, extending the cognitively healthy life expectancy.
DISCUSSION
These findings underscore the importance of promoting healthy lifestyles to delay cognitive decline, regardless of genetic predispositions, particularly in the Asian context.
Highlights
Compared with ε3 homozygotes, APOE ε4 carriers in China have a higher risk of transitioning from CH to CI, and APOE ε2 carriers with CH have a lower risk of transitioning to death.
Healthy lifestyles can extend life expectancy, primarily extending CH life expectancy.
Healthy lifestyles reduce the risk of CI and delay its onset in later life, regardless of APOE genetic risk.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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