基于发光纳米粒子和微流控生物芯片以及机器视觉算法分析的智能护理点生物传感平台

IF 26.6 1区材料科学 Q1 Engineering

Nano-Micro Letters Pub Date : 2025-04-14 DOI:10.1007/s40820-025-01745-w

Yuan Liu, Xinyue Lao, Man-Chung Wong, Menglin Song, Yifei Zhao, Yingjin Ma, Qianqian Bai, Jianhua Hao

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引用次数: 0

摘要

提出了一种由量子点发光和生物芯片结合机器视觉算法组成的新型智能生物传感平台，用于即时诊断癌胚抗原（CEA）蛋白。与一些商业生物检测设备的横向流动试验条相比，所设计的诊断平台具有突出的检测限，CEA浓度约为0.021 ng mL−1。机器视觉算法的应用提高了检测的便携性和集成性，扩大了即时生物传感应用的潜力。

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Intelligent Point-of-Care Biosensing Platform Based on Luminescent Nanoparticles and Microfluidic Biochip with Machine Vision Algorithm Analysis

Highlights

A novel intelligent biosensing platform consisting of quantum dots luminescence and biochip with machine vision algorithm is proposed for point-of-care carcinoembryonic antigen (CEA) protein diagnostics.
The designed diagnostic platform possesses outstanding detection limitation of approximately 0.021 ng mL⁻¹ of CEA concentration compared with some commercial biodetection devices of lateral flow assay strips.
The utilization of machine vision algorithm improves the detection features of portability and integration, which expands the potential of point-of-care biosensing applications.

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来源期刊

Nano-Micro Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

32.60

自引率

4.90%

发文量

981

审稿时长

1.1 months

期刊介绍： Nano-Micro Letters is a peer-reviewed, international, interdisciplinary, and open-access journal published under the SpringerOpen brand. Nano-Micro Letters focuses on the science, experiments, engineering, technologies, and applications of nano- or microscale structures and systems in various fields such as physics, chemistry, biology, material science, and pharmacy.It also explores the expanding interfaces between these fields. Nano-Micro Letters particularly emphasizes the bottom-up approach in the length scale from nano to micro. This approach is crucial for achieving industrial applications in nanotechnology, as it involves the assembly, modification, and control of nanostructures on a microscale.