陀螺仪放射外科系统交付质量保证中的点剂量验证

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2025-04-10 DOI:10.1016/j.radphyschem.2025.112798

Yagiz Yedekci , Huseyin Kıvanc , Fatih Biltekin , Demet Yildiz , Gozde Yazici , Gokhan Ozyigit

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引用次数: 0

摘要

目的：本研究旨在评估在zpac - x陀螺放射外科系统中使用Semiflex®3D电离室进行患者特异性递送质量保证（PS-DQA）的可行性和准确性。材料与方法采用ZAP-X系统对110例患者的184个病变进行了sps - dqa测量。目标体积范围从11 mm3到63044 mm3，平均为4321 mm3。使用ZAP-X治疗计划系统（TPS）制定治疗计划，该系统利用射线追踪算法进行剂量计算。PS-DQA采用水等效球形模体和Semiflex®3D电离室进行。以0.625 mm CT层厚扫描幻体，并在幻体CT数据集上重新计算治疗方案。分析了测量剂量和计划剂量之间的百分比差异，重点是不同的靶体积类别和小型准直器（4毫米和5毫米）的使用。统计学分析评估观察到的差异的显著性。结果大多数PS-DQA测量（84%）显示与计划剂量相比-5%和+5%之间的差异。然而，较小的靶体积（0-500 mm3）显示出明显更高的百分比差异，突出了这些领域剂量测量精度的挑战。当广泛使用小型准直器时，特别是当它们的使用超过总等心器的75%时，也观察到更大的剂量差异。Tukey HSD测试证实了基于靶体积和准直器尺寸的组间差异具有统计学意义。该研究证实了PS-DQA与Semiflex®3D电离室在ZAP-X系统中的可行性，同时强调了小靶体积和大量使用小型准直器的挑战。

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Point Dose Verification in Delivery Quality Assurance for Gyroscopic Radiosurgery System

Aim

This study aimed to evaluate the feasibility and accuracy of patient-specific delivery quality assurance (PS-DQA) using the Semiflex®3D ionization chamber within the ZAP-X gyroscopic radiosurgery system.

Materials and Methods

PS-DQA measurements were performed on 110 patients with 184 lesions treated using the ZAP-X system. Target volumes ranged from 11 mm³ to 63,044 mm³, with a mean of 4,321 mm³. Treatment plans were developed using the ZAP-X Treatment Planning System (TPS), which utilizes a ray-tracing algorithm for dose calculation. PS-DQA was conducted using a water-equivalent spherical phantom and the Semiflex®3D ionization chamber. The phantom was scanned with 0.625 mm CT slice thickness, and treatment plans were recalculated on the phantom’s CT dataset. The percentage differences between measured and planned doses were analyzed, focusing on different target volume categories and the use of small collimators (4 mm and 5 mm). Statistical analysis assessed the significance of observed differences.

Results

Most PS-DQA measurements (84%) showed discrepancies between -5% and +5% compared to planned doses. However, smaller target volumes (0-500 mm³) exhibited significantly higher percentage differences, highlighting challenges in dose measurement accuracy for these fields. Greater dose discrepancies were also observed when small collimators were extensively used, particularly when their usage exceeded 75% of total isocenters. Tukey HSD tests confirmed statistically significant differences between groups based on target volume and collimator size.

Conclusion

The study confirms the feasibility of PS-DQA with the Semiflex®3D ionization chamber in the ZAP-X system while highlighting challenges with small target volumes and extensive use of small collimators.

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.