探索双核过渡金属配合物的光物理、光化学和光生物动力学动态

IF 23.5 1区 化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR
Rintu Bhowmik , Abhishek Panwar , Gobinda Bag , Mithun Roy
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引用次数: 0

摘要

过渡金属配合物由于其不同的键模式、对称性以及受金属氧化态和配位影响的可调性质,在医学和生物应用中具有重要的潜力。这些复合物的光活化,特别是在抗癌研究中,为利用金属中心光化学机制开发选择性药物提供了一条途径。激发后,这些复合物可以通过辐射、非辐射或化学途径衰变,从而实现配体解离和氧化变化等过程,这对治疗应用至关重要。双金属配合物利用其增强的光化学和光物理特性,在光活化治疗中具有优越的性能,已成为癌症治疗中有希望的候选者。通过将不同的金属与互补的作用机制相结合,这些配合物提供了协同治疗效果,减少了副作用,与单金属系统相比,提高了疗效。这些双金属体系包括同核、异核过渡金属与一些同核和异核末端配体结合适当的桥接配体。在此,我们讨论了大量双金属系统在抗癌和其他治疗方面的光物理、光化学和光生物学方面的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exploring photophysical, photochemical, and photobiological dynamics of binuclear transition metal complexes

Exploring photophysical, photochemical, and photobiological dynamics of binuclear transition metal complexes
Complexes of transition metals hold significant potential for use in medicinal and biological applications due to their diverse bonding modes, symmetry, and tunable properties influenced by the metal's oxidation state and coordination. The photoactivation of these complexes, particularly in anticancer research, offers a pathway for developing selective drugs by leveraging metal-centered photochemical mechanisms. Upon excitation, these complexes can decay through radiative, non-radiative, or chemical pathways, enabling processes like ligand dissociation and oxidative changes that are crucial for therapeutic applications. Bimetallic complexes have emerged as promising candidates in cancer therapy, exploiting their enhanced photochemical and photophysical properties for superior performance in photoactivated treatments. By combining distinct metals with complementary mechanisms of action, these complexes offer synergistic therapeutic effects, reduced side effects, and improved efficacy compared to monometallic systems. These bimetallic systems involve homonuclear, heteronuclear transition metals with several homoleptic as well as heteroleptic terminal ligands combined with proper bridging ligands. Herein, we have discussed the photophysical, photochemical and photobiological aspects of plenty of bimetallic systems towards anticancer and other therapeutic applications.
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来源期刊
Coordination Chemistry Reviews
Coordination Chemistry Reviews 化学-无机化学与核化学
CiteScore
34.30
自引率
5.30%
发文量
457
审稿时长
54 days
期刊介绍: Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers. The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.
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