Rintu Bhowmik , Abhishek Panwar , Gobinda Bag , Mithun Roy
{"title":"探索双核过渡金属配合物的光物理、光化学和光生物动力学动态","authors":"Rintu Bhowmik , Abhishek Panwar , Gobinda Bag , Mithun Roy","doi":"10.1016/j.ccr.2025.216689","DOIUrl":null,"url":null,"abstract":"<div><div>Complexes of transition metals hold significant potential for use in medicinal and biological applications due to their diverse bonding modes, symmetry, and tunable properties influenced by the metal's oxidation state and coordination. The photoactivation of these complexes, particularly in anticancer research, offers a pathway for developing selective drugs by leveraging metal-centered photochemical mechanisms. Upon excitation, these complexes can decay through radiative, non-radiative, or chemical pathways, enabling processes like ligand dissociation and oxidative changes that are crucial for therapeutic applications. Bimetallic complexes have emerged as promising candidates in cancer therapy, exploiting their enhanced photochemical and photophysical properties for superior performance in photoactivated treatments. By combining distinct metals with complementary mechanisms of action, these complexes offer synergistic therapeutic effects, reduced side effects, and improved efficacy compared to monometallic systems. These bimetallic systems involve homonuclear, heteronuclear transition metals with several homoleptic as well as heteroleptic terminal ligands combined with proper bridging ligands. Herein, we have discussed the photophysical, photochemical and photobiological aspects of plenty of bimetallic systems towards anticancer and other therapeutic applications.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"537 ","pages":"Article 216689"},"PeriodicalIF":23.5000,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring photophysical, photochemical, and photobiological dynamics of binuclear transition metal complexes\",\"authors\":\"Rintu Bhowmik , Abhishek Panwar , Gobinda Bag , Mithun Roy\",\"doi\":\"10.1016/j.ccr.2025.216689\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Complexes of transition metals hold significant potential for use in medicinal and biological applications due to their diverse bonding modes, symmetry, and tunable properties influenced by the metal's oxidation state and coordination. The photoactivation of these complexes, particularly in anticancer research, offers a pathway for developing selective drugs by leveraging metal-centered photochemical mechanisms. Upon excitation, these complexes can decay through radiative, non-radiative, or chemical pathways, enabling processes like ligand dissociation and oxidative changes that are crucial for therapeutic applications. Bimetallic complexes have emerged as promising candidates in cancer therapy, exploiting their enhanced photochemical and photophysical properties for superior performance in photoactivated treatments. By combining distinct metals with complementary mechanisms of action, these complexes offer synergistic therapeutic effects, reduced side effects, and improved efficacy compared to monometallic systems. These bimetallic systems involve homonuclear, heteronuclear transition metals with several homoleptic as well as heteroleptic terminal ligands combined with proper bridging ligands. Herein, we have discussed the photophysical, photochemical and photobiological aspects of plenty of bimetallic systems towards anticancer and other therapeutic applications.</div></div>\",\"PeriodicalId\":289,\"journal\":{\"name\":\"Coordination Chemistry Reviews\",\"volume\":\"537 \",\"pages\":\"Article 216689\"},\"PeriodicalIF\":23.5000,\"publicationDate\":\"2025-04-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Coordination Chemistry Reviews\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0010854525002590\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coordination Chemistry Reviews","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010854525002590","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Exploring photophysical, photochemical, and photobiological dynamics of binuclear transition metal complexes
Complexes of transition metals hold significant potential for use in medicinal and biological applications due to their diverse bonding modes, symmetry, and tunable properties influenced by the metal's oxidation state and coordination. The photoactivation of these complexes, particularly in anticancer research, offers a pathway for developing selective drugs by leveraging metal-centered photochemical mechanisms. Upon excitation, these complexes can decay through radiative, non-radiative, or chemical pathways, enabling processes like ligand dissociation and oxidative changes that are crucial for therapeutic applications. Bimetallic complexes have emerged as promising candidates in cancer therapy, exploiting their enhanced photochemical and photophysical properties for superior performance in photoactivated treatments. By combining distinct metals with complementary mechanisms of action, these complexes offer synergistic therapeutic effects, reduced side effects, and improved efficacy compared to monometallic systems. These bimetallic systems involve homonuclear, heteronuclear transition metals with several homoleptic as well as heteroleptic terminal ligands combined with proper bridging ligands. Herein, we have discussed the photophysical, photochemical and photobiological aspects of plenty of bimetallic systems towards anticancer and other therapeutic applications.
期刊介绍:
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.