吸入器使用中的反安慰剂效应:患者的信念和治疗依从性

IF 1.8 Q3 PHARMACOLOGY & PHARMACY
Eduardo Garcia-Pachon , María J. Soler-Sempere , Sandra Ruiz-Alcaraz , Ana Ibarra-Macia , Marina Belendez-Vazquez
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引用次数: 0

摘要

反安慰剂效应是指由于药物治疗而产生的非特异性症状,这些症状不能用药物的药理作用来解释。这种将症状与治疗错误地联系起来的现象可能对治疗依从性产生重大影响,并可能导致患者对医疗援助的需求增加。目的确定吸入器使用引起的反安慰剂效应的频率和类型,以及相关因素。方法对吸入器不良反应进行问卷调查。此外,对吸入器的一般和特定药物的信念以及对药物量表的感知敏感性进行问卷调查。通过吸入器依从性测试和药房的电子处方补充率来确定吸入治疗的依从性。结果共纳入134例患者,其中21例(16%)将症状归因于吸入器,被认为是由于反安慰剂效应引起的。出现反安慰剂相关症状的患者对使用吸入器表现出更大的担忧,对药物作用更敏感,治疗依从性更低。结论接受吸入器治疗的患者中有相当一部分出现了不能合理归因于吸入器本身的阴性症状。倾向于将非特异性症状归因于吸入器的患者对药物的看法不同,并且与其他人相比,对治疗的依从性较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nocebo effect in inhaler use: Patients' beliefs and treatment adherence

Background

The nocebo effect refers to the experience of nonspecific symptoms attributed to medical treatments, which cannot be explained by the pharmacological effects of the medication. This phenomenon, where symptoms are incorrectly linked to a treatment, can have significant implications for treatment adherence and may lead to increased patient demand for medical assistance.

Objective

To ascertain the frequency and types of nocebo effects attributed to inhaler use, along with the associated factors.

Methods

An interview was conducted to inquire about adverse effects attributed to inhalers. Additionally, questionnaires on beliefs about medications, general and specific to inhalers, and perceived sensitivity to medications scale were administered. Adherence to inhaled therapy was established using the inhaler adherence test and the electronic prescription refill rate at the pharmacy.

Results

A total of 134 patients were included, among whom 21 (16 %) attributed symptoms to inhalers that were considered to be due to the nocebo effect. Patients experiencing nocebo-related symptoms exhibited greater concerns about using inhalers, heightened sensitivity to drug effects, and lower therapeutic adherence.

Conclusions

A significant proportion of patients receiving inhaler therapy associate negative symptoms that are not reasonably attributable to the inhalers themselves. Patients prone to attributing nonspecific symptoms to inhalers differ in their beliefs about medications and exhibit lower therapeutic adherence compared to others.
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CiteScore
1.60
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