体重指数和霍奇金淋巴瘤的风险：来自挪威队列研究的见解

IF 7.6 1区医学 Q1 ONCOLOGY

European Journal of Cancer Pub Date : 2025-04-02 DOI:10.1016/j.ejca.2025.115400

Dagfinn Aune , Marie Nordsletten , Tor Åge Myklebust , Trude Eid Robsahm , Bjørn Steen Skålhegg , Tom Mala , Sheraz Yaqub , Usman Saeed

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引用次数: 0

摘要

背景有多项研究报告称，较高的体重指数（BMI）与罹患霍奇金淋巴瘤的风险呈正相关。然而，证据并不完全一致。方法分析数据集包括1963-1975年基线年龄在16-75岁之间的1723692名男性和女性。结果在5610万人年的随访期间，共发生1608例霍奇金淋巴瘤病例。与 BMI 为 18.5-< 25 的人相比，BMI 为 15-< 18.5、25-< 30 和≥30 的人的 HRs（95 % CIs）分别为 0.87 (0.59-1.27)、1.05 (0.94-1.18) 和 1.61 (1.35-1.91)，肥胖 1 级和 2 级的 HRs 分别为 1.57 (1.30-1.90) 和 1.80 (1.24-2.62)。每增加 5 kg/m2 还可观察到正相关，总体 HR（95 % CI）为 1.16（1.08-1.24），女性为 1.20（1.09-1.31），男性为 1.08（0.96-1.20）。还观察到成年早期（16-29 岁）肥胖与正常体重和霍奇金淋巴瘤（HR，95 % CIs：1.89，1.10-3.22，ptrend<0.0001，n = 489 例）之间以及肥胖与早发疾病（诊断时年龄为 50 岁）（HR，95 % CIs：1.结论在总体体重指数（BMI）较高和青年期体重指数（BMI）较高与霍奇金淋巴瘤之间以及体重指数（BMI）较高与早发疾病之间观察到的正相关强调了肥胖在这种恶性肿瘤发病中的潜在作用。

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Body mass index and risk of Hodgkin's lymphoma: Insights from a Norwegian cohort study

Background

Several studies have reported positive associations between higher body mass index (BMI) and risk of Hodgkin's lymphoma. However, the evidence is not entirely consistent. We investigated the association between BMI and Hodgkin's lymphoma in a large Norwegian cohort with up to 50 years follow-up.

Methods

The analytical dataset included 1723,692 men and women aged 16–75 years at baseline in 1963–1975. Multivariable Cox regression analyses were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the associations between BMI and Hodgkin's lymphoma incidence.

Results

During 56.1 million person-years of follow-up, 1608 incident Hodgkin's lymphoma cases occurred. Compared to individuals with BMI 18.5-< 25, the HRs (95 % CIs) for those with a BMI of 15-< 18.5, 25-< 30, and ≥ 30 were 0.87 (0.59–1.27), 1.05 (0.94–1.18), and 1.61 (1.35–1.91), respectively, and 1.57 (1.30–1.90) and 1.80 (1.24–2.62) for obesity grade 1 and grade 2, respectively. A positive association was also observed per 5 kg/m² increment with a HR (95 % CI) of 1.16 (1.08–1.24) overall, 1.20 (1.09–1.31) in women, and 1.08 (0.96–1.20) in men. Positive associations were also observed between obesity vs. normal weight in early adulthood (age 16–29 years) and Hodgkin's lymphoma (HR, 95 % CIs: 1.89, 1.10–3.22, p_trend<0.0001, n = 489 cases) and between obesity and early-onset (age <50 years at diagnosis) disease (HR, 95 % CIs: 1.67, 1.01–2.78, p_trend<0.0001, n = 393 cases).

Conclusion

The positive associations observed between higher BMI overall and in young adulthood and Hodgkin's lymphoma and between BMI and early-onset disease emphasize the potential role of adiposity in development of this malignancy.

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来源期刊

European Journal of Cancer 医学-肿瘤学

CiteScore

11.50

自引率

4.80%

发文量

953

审稿时长

23 days

期刊介绍： The European Journal of Cancer (EJC) serves as a comprehensive platform integrating preclinical, digital, translational, and clinical research across the spectrum of cancer. From epidemiology, carcinogenesis, and biology to groundbreaking innovations in cancer treatment and patient care, the journal covers a wide array of topics. We publish original research, reviews, previews, editorial comments, and correspondence, fostering dialogue and advancement in the fight against cancer. Join us in our mission to drive progress and improve outcomes in cancer research and patient care.