转移性乳腺癌的放射配体治疗：利用精确肿瘤学

IF 9.6 1区医学 Q1 ONCOLOGY

Cancer treatment reviews Pub Date : 2025-04-08 DOI:10.1016/j.ctrv.2025.102940

Federica Giugliano , Elisa Giordano , Laura Gilardi , Beatrice Taurelli Salimbeni , Paola Zagami , Angela Esposito , Antonio Marra , Dario Trapani , Pier Paolo Maria Berton Giachetti , Bianca Malagutti , Théophraste Henry , Desiree Deandreis , Giuseppe Curigliano , Francesco Ceci , Carmen Criscitiello

{"title":"转移性乳腺癌的放射配体治疗：利用精确肿瘤学","authors":"Federica Giugliano , Elisa Giordano , Laura Gilardi , Beatrice Taurelli Salimbeni , Paola Zagami , Angela Esposito , Antonio Marra , Dario Trapani , Pier Paolo Maria Berton Giachetti , Bianca Malagutti , Théophraste Henry , Desiree Deandreis , Giuseppe Curigliano , Francesco Ceci , Carmen Criscitiello","doi":"10.1016/j.ctrv.2025.102940","DOIUrl":null,"url":null,"abstract":"<div><div>Radioligand therapy (RLT) represents a promising advancement in precision oncology and enables the targeted delivery of radiation to cancer cells. This approach has shown success in other tumor types, such as prostate cancer and neuroendocrine tumors. Its potential in metastatic breast cancer (mBC) is currently under investigation. This review discusses RLT mechanism of action, therapeutic potential, and integration into the existing therapeutic landscape of mBC. While clinical trials have shown promising results, challenges remain regarding target heterogeneity, implementation, and optimizing treatment strategies. Further research is essential to integrate RLT into clinical practice and improve patient outcomes fully.</div></div>","PeriodicalId":9537,"journal":{"name":"Cancer treatment reviews","volume":"136 ","pages":"Article 102940"},"PeriodicalIF":9.6000,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Radioligand Therapy in Metastatic Breast Cancer: Harnessing Precision Oncology\",\"authors\":\"Federica Giugliano , Elisa Giordano , Laura Gilardi , Beatrice Taurelli Salimbeni , Paola Zagami , Angela Esposito , Antonio Marra , Dario Trapani , Pier Paolo Maria Berton Giachetti , Bianca Malagutti , Théophraste Henry , Desiree Deandreis , Giuseppe Curigliano , Francesco Ceci , Carmen Criscitiello\",\"doi\":\"10.1016/j.ctrv.2025.102940\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Radioligand therapy (RLT) represents a promising advancement in precision oncology and enables the targeted delivery of radiation to cancer cells. This approach has shown success in other tumor types, such as prostate cancer and neuroendocrine tumors. Its potential in metastatic breast cancer (mBC) is currently under investigation. This review discusses RLT mechanism of action, therapeutic potential, and integration into the existing therapeutic landscape of mBC. While clinical trials have shown promising results, challenges remain regarding target heterogeneity, implementation, and optimizing treatment strategies. Further research is essential to integrate RLT into clinical practice and improve patient outcomes fully.</div></div>\",\"PeriodicalId\":9537,\"journal\":{\"name\":\"Cancer treatment reviews\",\"volume\":\"136 \",\"pages\":\"Article 102940\"},\"PeriodicalIF\":9.6000,\"publicationDate\":\"2025-04-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer treatment reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0305737225000623\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer treatment reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0305737225000623","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

放射配体治疗（RLT）代表了精确肿瘤学的一个有前途的进步，能够靶向地向癌细胞传递辐射。这种方法在其他类型的肿瘤，如前列腺癌和神经内分泌肿瘤中取得了成功。目前正在研究其在转移性乳腺癌（mBC）中的潜力。本文综述了RLT的作用机制、治疗潜力以及与现有治疗方案的整合。虽然临床试验显示出有希望的结果，但在目标异质性、实施和优化治疗策略方面仍然存在挑战。进一步的研究是将RLT纳入临床实践和充分改善患者预后的必要条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Radioligand Therapy in Metastatic Breast Cancer: Harnessing Precision Oncology

Radioligand therapy (RLT) represents a promising advancement in precision oncology and enables the targeted delivery of radiation to cancer cells. This approach has shown success in other tumor types, such as prostate cancer and neuroendocrine tumors. Its potential in metastatic breast cancer (mBC) is currently under investigation. This review discusses RLT mechanism of action, therapeutic potential, and integration into the existing therapeutic landscape of mBC. While clinical trials have shown promising results, challenges remain regarding target heterogeneity, implementation, and optimizing treatment strategies. Further research is essential to integrate RLT into clinical practice and improve patient outcomes fully.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cancer treatment reviews 医学-肿瘤学

CiteScore

21.40

自引率

0.80%

发文量

109

审稿时长

13 days

期刊介绍： Cancer Treatment Reviews Journal Overview: International journal focused on developments in cancer treatment research Publishes state-of-the-art, authoritative reviews to keep clinicians and researchers informed Regular Sections in Each Issue: Comments on Controversy Tumor Reviews Anti-tumor Treatments New Drugs Complications of Treatment General and Supportive Care Laboratory/Clinic Interface Submission and Editorial System: Online submission and editorial system for Cancer Treatment Reviews