托卡特省G蛋白偶联雌激素受体（GPER）对COVID-19病例诊断价值的评价

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Steroids Pub Date : 2025-04-11 DOI:10.1016/j.steroids.2025.109605

Figen Guzelgul , Ergul Belge Kurutas

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引用次数: 0

摘要

目的影响 COVID-19 （一种由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的人类呼吸道传染病）临床病程的因素仍然鲜为人知。G 蛋白偶联雌激素受体（GPER）是一种由人类 GPER 基因编码的蛋白质。GPER 与雌性激素雌二醇结合后被激活，从而介导雌二醇对细胞的快速作用。本研究首次对 COVID-19 患者的 GPER 水平及其诊断价值进行了研究。方法：本研究共纳入 71 名患者[女性/男性（n = 36/35），年龄在 32 ∼ 62 岁之间]，并将其分为三组：患者组包括确诊为 COVID-19 并在重症监护室（ICU）接受支持性治疗的患者；轻度组包括接受门诊治疗的 COVID-19 患者；对照组。结果分析了患者的性别分布，结果显示男性 35 人（49.3%），女性 36 人（50.7%）。与对照组和轻度病程组相比，重度 COVID-19 女性患者的 GPER 水平明显升高（p < 0.05）。该研究首次表明，女性患者的GPER水平与COVID-19的严重程度明显相关，这表明GPER可作为COVID-19病情发展的诊断标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Evaluation of the diagnostic value of G protein-coupled estrogen receptor (GPER) in COVID-19 cases at Tokat Province

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Evaluation of the diagnostic value of G protein-coupled estrogen receptor (GPER) in COVID-19 cases at Tokat Province

Objective

Factors affecting the clinical course of COVID-19, an infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, are still poorly understood. G protein-coupled estrogen receptor (GPER) is a protein encoded by the GPER gene in humans. GPER is activated by binding to estradiol, a female sex hormone, leading to mediation of estradiol’s rapid cellular effects. In this study, which was conducted for the first time, we aimed to investigate GPER levels and their diagnostic value in COVID-19 patients.

Methods

A total of 71 individuals [Female/Male (n = 36/35) range of ages 32 ∼ 62] were enrolled in this study and categorized into three groups: the patient group consisted of individuals diagnosed with COVID-19 and receiving supportive treatment in the intensive care unit (ICU), the mild group consisted of COVID-19 patients who received outpatient treatment, and the control group. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum GPER levels.

Results

The general sex distribution of the patients was analyzed, revealing that 35(49.3 %) were male and 36(50.7 %) were female. GPER levels were significantly increased in severe COVID-19 females compared to control and mild course groups (p < 0.05). A GPER cut-off value of 2.95 ng/mL showed diagnostic accuracy in severe COVID-19 cases.

Conclusion

This study, conducted for the first time, demonstrates that GPER levels are significantly associated with COVID-19 severity in female patients, suggesting that GPER may serve as a diagnostic marker for the progression of COVID-19.

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.